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Gene Review

KCNE2  -  potassium voltage-gated channel, Isk...

Canis lupus familiaris

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Disease relevance of KCNE2

  • Mutations in minK-related peptide 1 (MiRP1), the product of the KCNE2 gene, have been associated with malignant ventricular arrhythmia syndromes related to impaired repolarization [1].
  • BACKGROUND: Mutations in KCNE2 have been linked to long-QT syndrome (LQT6), yet KCNE2 protein expression in the ventricle and its functional role in native channels are not clear [2].

High impact information on KCNE2


Analytical, diagnostic and therapeutic context of KCNE2

  • METHODS AND RESULTS: We detected KCNE2 protein in human, dog, and rat ventricles in Western blot experiments [2].


  1. Canine ventricular KCNE2 expression resides predominantly in Purkinje fibers. Pourrier, M., Zicha, S., Ehrlich, J., Han, W., Nattel, S. Circ. Res. (2003) [Pubmed]
  2. KCNE2 protein is expressed in ventricles of different species, and changes in its expression contribute to electrical remodeling in diseased hearts. Jiang, M., Zhang, M., Tang, D.G., Clemo, H.F., Liu, J., Holwitt, D., Kasirajan, V., Pond, A.L., Wettwer, E., Tseng, G.N. Circulation (2004) [Pubmed]
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