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Chemical Compound Review

Dobutrex     4-[2-[4-(4- hydroxyphenyl)butan-2...

Synonyms: Inotrex, Dobutamina, dobutamine, Dobutaminum, DL-dobutamine, ...
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Disease relevance of dobutamine


Psychiatry related information on dobutamine

  • CONCLUSIONS: Analysis of Color Kinesis images allows fast, objective, and automated evaluation of regional wall motion sensitively enough to evaluate clinical dobutamine stress data [5].
  • For the evaluation of the haemodynamic importance of myocardial bridging, intracoronary Doppler flow velocity measurements and angiography during dobutamine stress may be helpful in clinical decision making [6].
  • Compared with modalities used in other studies, shorter infusion periods with higher dobutamine doses allowed a higher stress intensity to be reached without reducing patient compliance [7].
  • In the standard open field and social interaction tests, which also include an anxiety component, the beneficial effects of dobutamine were not observed [8].
  • In the free exploration test, which primarily evaluates exploratory behavior, dobutamine normalized the reduced interest in the environment [8].

High impact information on dobutamine


Chemical compound and disease context of dobutamine


Biological context of dobutamine

  • While increased heart rate after dobutamine markedly increased contractility, Ea was not changed, and neither stroke work nor pressure-volume was further increased [16].
  • Hemodynamics during exercise were maintained the same as pretreatment base line for the dobutamine and exercise groups, whereas stroke volume and cardiac output dropped and heart rate rose for the saline group [17].
  • Maximal exercise (duration, oxygen consumption, and workload) fell for the saline group and remained unchanged for the dobutamine and exercise groups [17].
  • Dobutamine also reduced the minimum diastolic pressure from 14 +/- 7 to 10 +/- 9 mm Hg (p less than .01); neither drug reduced end-diastolic pressure [18].
  • After dobutamine, the slope of transition of wall thickening from nonischemic to ischemic zones, measured directly from the left ventricular function map, increased on the free wall border (0.71 +/- 0.11 to 0.95 +/- 0.10, p less than .02) to a greater extent than on the septal border (0.60 +/- 0.08 to 0.73 +/- 0.06, p = .07) [19].

Anatomical context of dobutamine

  • We infused dobutamine into the left main coronary artery of 24 patients with severe congestive heart failure (CHF) and 8 normal subjects without hemodynamic dysfunction [20].
  • This study was undertaken to determine whether this biphasic pattern of regional function characterizes the response of ischemic or hibernating myocardium to dobutamine and to explore the factors and mechanisms that determine this response [21].
  • Dobutamine produced a 34 +/- 3% increase in cardiac index, no significant change in systemic arterial pressures, a decrease in pulmonary artery diastolic and right atrial pressures, and no change in heart rate or forearm vascular resistance (from 30.2 +/- 4.3 to 26.5 +/- 4.7 units, p = NS).(ABSTRACT TRUNCATED AT 400 WORDS)[22]
  • Measurement of the constant of isovolumic relaxation of the left ventricle (tau) demonstrated a similar benefit of the dobutamine infusion for overcoming postresuscitation diastolic dysfunction [23].
  • On the two-dimensional echocardiograms, the position of coaptation of the mitral valve was shifted closer to the base of the anterior leaflet in the presence of dobutamine-induced SAM than before the drug was administered [24].

Associations of dobutamine with other chemical compounds


Gene context of dobutamine


Analytical, diagnostic and therapeutic context of dobutamine


  1. Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses. Pijls, N.H., De Bruyne, B., Peels, K., Van Der Voort, P.H., Bonnier, H.J., Bartunek J Koolen, J.J., Koolen, J.J. N. Engl. J. Med. (1996) [Pubmed]
  2. A comparison of digoxin and dobutamine in patients with acute infarction and cardiac failure. Goldstein, R.A., Passamani, E.R., Roberts, R. N. Engl. J. Med. (1980) [Pubmed]
  3. Elevation of systemic oxygen delivery in the treatment of critically ill patients. Hayes, M.A., Timmins, A.C., Yau, E.H., Palazzo, M., Hinds, C.J., Watson, D. N. Engl. J. Med. (1994) [Pubmed]
  4. Dobutamine therapy in acute myocardial infarction. Keung, E.C., Siskind, S.J., Sonneblick, E.H., Ribner, H.S., Schwartz, W.J., LeJemtel, T.H. JAMA (1981) [Pubmed]
  5. Segmental analysis of color kinesis images: new method for quantification of the magnitude and timing of endocardial motion during left ventricular systole and diastole. Mor-Avi, V., Vignon, P., Koch, R., Weinert, L., Garcia, M.J., Spencer, K.T., Lang, R.M. Circulation (1997) [Pubmed]
  6. Myocardial bridging in a survivor of sudden cardiac near-death: role of intracoronary doppler flow measurements and angiography during dobutamine stress in the clinical evaluation. Tio, R.A., Van Gelder, I.C., Boonstra, P.W., Crijns, H.J. Heart (1997) [Pubmed]
  7. Lack of clinically significant cardiac dysfunction during intermediate dobutamine doses in long-term childhood cancer survivors exposed to anthracyclines. Lanzarini, L., Bossi, G., Laudisa, M.L., Klersy, C., Aricò, M. Am. Heart J. (2000) [Pubmed]
  8. 'Quality of life' after therapy in rats with myocardial infarction: dissociation between hemodynamic and behavioral improvement. Schoemaker, R.G., Kalkman, E.A., Smits, J.F. Eur. J. Pharmacol. (1996) [Pubmed]
  9. Demonstration of an in vivo functional beta 3-adrenoceptor in man. Enocksson, S., Shimizu, M., Lönnqvist, F., Nordenström, J., Arner, P. J. Clin. Invest. (1995) [Pubmed]
  10. Role of nitric oxide in parasympathetic modulation of beta-adrenergic myocardial contractility in normal dogs. Hare, J.M., Keaney, J.F., Balligand, J.L., Loscalzo, J., Smith, T.W., Colucci, W.S. J. Clin. Invest. (1995) [Pubmed]
  11. Metolazone in treatment of severe refractory congestive cardiac failure. Kiyingi, A., Field, M.J., Pawsey, C.C., Yiannikas, J., Lawrence, J.R., Arter, W.J. Lancet (1990) [Pubmed]
  12. Comparison of adenosine, dipyridamole, and dobutamine in stress echocardiography. Martin, T.W., Seaworth, J.F., Johns, J.P., Pupa, L.E., Condos, W.R. Ann. Intern. Med. (1992) [Pubmed]
  13. Combined hemodynamic effects of dopamine and dobutamine in cardiogenic shock. Richard, C., Ricome, J.L., Rimailho, A., Bottineau, G., Auzepy, P. Circulation (1983) [Pubmed]
  14. Effects of dobutamine at maximally tolerated dose on myocardial blood flow in humans with ischemic heart disease. Skopicki, H.A., Abraham, S.A., Picard, M.H., Alpert, N.M., Fischman, A.J., Gewirtz, H. Circulation (1997) [Pubmed]
  15. Milrinone, dobutamine, and nitroprusside: comparative effects on hemodynamics and myocardial energetics in patients with severe congestive heart failure. Monrad, E.S., Baim, D.S., Smith, H.S., Lanoue, A.S. Circulation (1986) [Pubmed]
  16. Role of ventriculovascular coupling in cardiac response to increased contractility in closed-chest dogs. Freeman, G.L., Colston, J.T. J. Clin. Invest. (1990) [Pubmed]
  17. Prevention of bedrest-induced physical deconditioning by daily dobutamine infusions. Implications for drug-induced physical conditioning. Sullivan, M.J., Binkley, P.F., Unverferth, D.V., Ren, J.H., Boudoulas, H., Bashore, T.M., Merola, A.J., Leier, C.V. J. Clin. Invest. (1985) [Pubmed]
  18. The differential effects of positive inotropic and vasodilator therapy on diastolic properties in patients with congestive cardiomyopathy. Carroll, J.D., Lang, R.M., Neumann, A.L., Borow, K.M., Rajfer, S.I. Circulation (1986) [Pubmed]
  19. The effect of inotropic stimulation on normal and ischemic myocardium after coronary occlusion. Buda, A.J., Zotz, R.J., Gallagher, K.P. Circulation (1987) [Pubmed]
  20. Intracoronary infusion of dobutamine to patients with and without severe congestive heart failure. Dose-response relationships, correlation with circulating catecholamines, and effect of phosphodiesterase inhibition. Colucci, W.S., Denniss, A.R., Leatherman, G.F., Quigg, R.J., Ludmer, P.L., Marsh, J.D., Gauthier, D.F. J. Clin. Invest. (1988) [Pubmed]
  21. Incremental doses of dobutamine induce a biphasic response in dysfunctional left ventricular regions subtending coronary stenoses. Chen, C., Li, L., Chen, L.L., Prada, J.V., Chen, M.H., Fallon, J.T., Weyman, A.E., Waters, D., Gillam, L. Circulation (1995) [Pubmed]
  22. Sympathoinhibitory responses to digitalis glycosides in heart failure patients. Direct evidence from sympathetic neural recordings. Ferguson, D.W., Berg, W.J., Sanders, J.S., Roach, P.J., Kempf, J.S., Kienzle, M.G. Circulation (1989) [Pubmed]
  23. Postresuscitation left ventricular systolic and diastolic dysfunction. Treatment with dobutamine. Kern, K.B., Hilwig, R.W., Berg, R.A., Rhee, K.H., Sanders, A.B., Otto, C.W., Ewy, G.A. Circulation (1997) [Pubmed]
  24. Production of systolic anterior motion of the mitral valve in dogs. Sakurai, S., Tanaka, H., Yoshimura, H., Nakao, S., Tahara, M. Circulation (1985) [Pubmed]
  25. Safety and tolerability of dobutamine-atropine stress echocardiography: a prospective, multicentre study. Echo Dobutamine International Cooperative Study Group. Picano, E., Mathias, W., Pingitore, A., Bigi, R., Previtali, M. Lancet (1994) [Pubmed]
  26. Dobutamine modulates lipopolysaccharide-induced macrophage inflammatory protein-1alpha and interleukin-8 production in human monocytes. Li, C.Y., Tsai, C.S., Hsu, P.C., Wu, C.T., Wong, C.S., Ho, S.T. Anesth. Analg. (2003) [Pubmed]
  27. Characterization of the acute cardiovascular effects of intravenously administered insulin-like growth factor-I in conscious sprague-dawley rats. Cao, N., Lau, S., Nguyen, T.T., White, P.J. Clin. Exp. Pharmacol. Physiol. (2006) [Pubmed]
  28. Catecholamine-provoked microvoltage T wave alternans in genotyped long QT syndrome. Nemec, J., Ackerman, M.J., Tester, D.J., Hejlik, J., Shen, W.K. Pacing and clinical electrophysiology : PACE. (2003) [Pubmed]
  29. Gene therapy in cardiac surgery: intramyocardial injection of naked plasmid DNA for chronic myocardial ischemia. Heilmann, C.A., Attmann, T., Thiem, A., Haffner, E., Beyersdorf, F., Lutter, G. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (2003) [Pubmed]
  30. The lack of cardiotrophin-1 alters expression of interleukin-6 and leukemia inhibitory factor mRNA but does not impair cardiac injury response. Gritman, K., Van Winkle, D.M., Lorentz, C.U., Pennica, D., Habecker, B.A. Cytokine (2006) [Pubmed]
  31. The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery. Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group. Poldermans, D., Boersma, E., Bax, J.J., Thomson, I.R., van de Ven, L.L., Blankensteijn, J.D., Baars, H.F., Yo, T.I., Trocino, G., Vigna, C., Roelandt, J.R., van Urk, H. N. Engl. J. Med. (1999) [Pubmed]
  32. Central nervous pathways mediating angina pectoris. Rosen, S.D., Paulesu, E., Frith, C.D., Frackowiak, R.S., Davies, G.J., Jones, T., Camici, P.G. Lancet (1994) [Pubmed]
  33. Drugs five years later. Dobutamine. Leier, C.V., Unverferth, D.V. Ann. Intern. Med. (1983) [Pubmed]
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