Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

COL4A3 - collagen, type IV, alpha 3 (Goodpasture...

Canis lupus familiaris

Wiersma, A.C. et al., Heidet, L. et al., Wiersma, A.C. et al.

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Disease relevance of COL4A3

Intron-exon boundaries in both genes were determined by BLAST analysis of the Canis Familiaris Trace Archive. The elucidation of the cDNA sequences, genomic organization and the open reading frames of canine COL4A3 and COL4A4 provide the groundwork for screening these genes for mutations in hereditary nephritis in dogs [1].

High impact information on COL4A3

We show that, independent of the type of mutation and of the level of COL4A5 transcription, both COL4A3 and COL4A4 genes are actively transcribed in podocytes [2].
The collagen type IV alpha3 and alpha4 chains (COL4A3 and COL4A4) are part of the specialized glomerular basement membrane in the kidney [3].

References

Canine COL4A3 and COL4A4: sequencing, mapping and genomic organization. Wiersma, A.C., Millon, L.V., Hestand, M.S., Van Oost, B.A., Bannasch, D.L. DNA Seq. (2005) [Pubmed]
Glomerular expression of type IV collagen chains in normal and X-linked Alport syndrome kidneys. Heidet, L., Cai, Y., Guicharnaud, L., Antignac, C., Gubler, M.C. Am. J. Pathol. (2000) [Pubmed]
Evaluation of canine COL4A3 and COL4A4 as candidates for familial renal disease in the Norwegian elkhound. Wiersma, A.C., Millon, L.V., van Dongen, A.M., van Oost, B.A., Bannasch, D.L. J. Hered. (2005) [Pubmed]

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