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MeSH Review


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Disease relevance of Podocytes


High impact information on Podocytes

  • Nck links nephrin to actin in kidney podocytes [4].
  • Two papers, one in Nature (Jones et al., 2006) and the other in the Journal of Clinical Investigation (Verma et al., 2006) show that Nck adaptor proteins connect phosphorylated nephrin with actin polymerization in podocyte foot processes, structures important for slit-diaphragm formation in the kidney [4].
  • Here, we show that the canonical transient receptor potential 6 (TRPC6) ion channel is expressed in podocytes and is a component of the glomerular slit diaphragm [5].
  • NPHS2 is almost exclusively expressed in the podocytes of fetal and mature kidney glomeruli, and encodes a new integral membrane protein, podocin, belonging to the stomatin protein family [6].
  • Microheterogeneity of protein and sterol content in kidney podocyte membrane [7].

Chemical compound and disease context of Podocytes


Biological context of Podocytes


Anatomical context of Podocytes


Associations of Podocytes with chemical compounds


Gene context of Podocytes

  • These data support the conclusion that the GLEPP1 (Ptpro) receptor plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function [14].
  • Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation [24].
  • TGF-beta1 and Smad7 each induce apoptosis in podocytes, and their coexpression has an additive effect [13].
  • The finding that this disease is caused by mutations in the transcription factor LMX1B, which in the kidney is expressed exclusively in podocytes, offers the opportunity for a better understanding of the renal pathogenesis [25].
  • For the earliest podocyte marker identified, Foxc2, knockout mice were used to analyze the role of this protein during glomerular development [26].

Analytical, diagnostic and therapeutic context of Podocytes


  1. Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin. Doyonnas, R., Kershaw, D.B., Duhme, C., Merkens, H., Chelliah, S., Graf, T., McNagny, K.M. J. Exp. Med. (2001) [Pubmed]
  2. Induction of B7-1 in podocytes is associated with nephrotic syndrome. Reiser, J., von Gersdorff, G., Loos, M., Oh, J., Asanuma, K., Giardino, L., Rastaldi, M.P., Calvaresi, N., Watanabe, H., Schwarz, K., Faul, C., Kretzler, M., Davidson, A., Sugimoto, H., Kalluri, R., Sharpe, A.H., Kreidberg, J.A., Mundel, P. J. Clin. Invest. (2004) [Pubmed]
  3. Basic fibroblast growth factor augments podocyte injury and induces glomerulosclerosis in rats with experimental membranous nephropathy. Floege, J., Kriz, W., Schulze, M., Susani, M., Kerjaschki, D., Mooney, A., Couser, W.G., Koch, K.M. J. Clin. Invest. (1995) [Pubmed]
  4. Nck links nephrin to actin in kidney podocytes. Tryggvason, K., Pikkarainen, T., Patrakka, J. Cell (2006) [Pubmed]
  5. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Reiser, J., Polu, K.R., Möller, C.C., Kenlan, P., Altintas, M.M., Wei, C., Faul, C., Herbert, S., Villegas, I., Avila-Casado, C., McGee, M., Sugimoto, H., Brown, D., Kalluri, R., Mundel, P., Smith, P.L., Clapham, D.E., Pollak, M.R. Nat. Genet. (2005) [Pubmed]
  6. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Boute, N., Gribouval, O., Roselli, S., Benessy, F., Lee, H., Fuchshuber, A., Dahan, K., Gubler, M.C., Niaudet, P., Antignac, C. Nat. Genet. (2000) [Pubmed]
  7. Microheterogeneity of protein and sterol content in kidney podocyte membrane. Orci, L., Singh, A., Amherdt, M., Brown, D., Perrelet, A. Nature (1981) [Pubmed]
  8. Early glomerular filtration defect and severe renal disease in podocin-deficient mice. Roselli, S., Heidet, L., Sich, M., Henger, A., Kretzler, M., Gubler, M.C., Antignac, C. Mol. Cell. Biol. (2004) [Pubmed]
  9. Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation. Saleem, M.A., Ni, L., Witherden, I., Tryggvason, K., Ruotsalainen, V., Mundel, P., Mathieson, P.W. Am. J. Pathol. (2002) [Pubmed]
  10. Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Susztak, K., Raff, A.C., Schiffer, M., Böttinger, E.P. Diabetes (2006) [Pubmed]
  11. Expression and function of C/EBP homology protein (GADD153) in podocytes. Bek, M.F., Bayer, M., Müller, B., Greiber, S., Lang, D., Schwab, A., August, C., Springer, E., Rohrbach, R., Huber, T.B., Benzing, T., Pavenstädt, H. Am. J. Pathol. (2006) [Pubmed]
  12. Identification of a 400-kd protein in the brush borders of human kidney tubules that is similar to gp330, the nephritogenic antigen of rat Heymann nephritis. Kerjaschki, D., Horvat, R., Binder, S., Susani, M., Dekan, G., Ojha, P.P., Hillemanns, P., Ulrich, W., Donini, U. Am. J. Pathol. (1987) [Pubmed]
  13. Apoptosis in podocytes induced by TGF-beta and Smad7. Schiffer, M., Bitzer, M., Roberts, I.S., Kopp, J.B., ten Dijke, P., Mundel, P., Böttinger, E.P. J. Clin. Invest. (2001) [Pubmed]
  14. Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate. Wharram, B.L., Goyal, M., Gillespie, P.J., Wiggins, J.E., Kershaw, D.B., Holzman, L.B., Dysko, R.C., Saunders, T.L., Samuelson, L.C., Wiggins, R.C. J. Clin. Invest. (2000) [Pubmed]
  15. Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner. Asanuma, K., Kim, K., Oh, J., Giardino, L., Chabanis, S., Faul, C., Reiser, J., Mundel, P. J. Clin. Invest. (2005) [Pubmed]
  16. The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death. Putaala, H., Soininen, R., Kilpeläinen, P., Wartiovaara, J., Tryggvason, K. Hum. Mol. Genet. (2001) [Pubmed]
  17. A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus. Srichai, M.B., Konieczkowski, M., Padiyar, A., Konieczkowski, D.J., Mukherjee, A., Hayden, P.S., Kamat, S., El-Meanawy, M.A., Khan, S., Mundel, P., Lee, S.B., Bruggeman, L.A., Schelling, J.R., Sedor, J.R. J. Biol. Chem. (2004) [Pubmed]
  18. Podoendin. A new cell surface protein of the podocyte and endothelium. Huang, T.W., Langlois, J.C. J. Exp. Med. (1985) [Pubmed]
  19. Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34. Sassetti, C., Tangemann, K., Singer, M.S., Kershaw, D.B., Rosen, S.D. J. Exp. Med. (1998) [Pubmed]
  20. Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. Mundel, P., Heid, H.W., Mundel, T.M., Krüger, M., Reiser, J., Kriz, W. J. Cell Biol. (1997) [Pubmed]
  21. Angiotensin II depolarizes podocytes in the intact glomerulus of the Rat. Gloy, J., Henger, A., Fischer, K.G., Nitschke, R., Mundel, P., Bleich, M., Schollmeyer, P., Greger, R., Pavenstädt, H. J. Clin. Invest. (1997) [Pubmed]
  22. Identification of a major sialoprotein in the glycocalyx of human visceral glomerular epithelial cells. Kerjaschki, D., Poczewski, H., Dekan, G., Horvat, R., Balzar, E., Kraft, N., Atkins, R.C. J. Clin. Invest. (1986) [Pubmed]
  23. Thrombomucin, a novel cell surface protein that defines thrombocytes and multipotent hematopoietic progenitors. McNagny, K.M., Pettersson, I., Rossi, F., Flamme, I., Shevchenko, A., Mann, M., Graf, T. J. Cell Biol. (1997) [Pubmed]
  24. Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation. Miner, J.H., Morello, R., Andrews, K.L., Li, C., Antignac, C., Shaw, A.S., Lee, B. J. Clin. Invest. (2002) [Pubmed]
  25. The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes. Rohr, C., Prestel, J., Heidet, L., Hosser, H., Kriz, W., Johnson, R.L., Antignac, C., Witzgall, R. J. Clin. Invest. (2002) [Pubmed]
  26. Large-scale identification of genes implicated in kidney glomerulus development and function. Takemoto, M., He, L., Norlin, J., Patrakka, J., Xiao, Z., Petrova, T., Bondjers, C., Asp, J., Wallgard, E., Sun, Y., Samuelsson, T., Mostad, P., Lundin, S., Miura, N., Sado, Y., Alitalo, K., Quaggin, S.E., Tryggvason, K., Betsholtz, C. EMBO J. (2006) [Pubmed]
  27. Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN. Donoviel, D.B., Freed, D.D., Vogel, H., Potter, D.G., Hawkins, E., Barrish, J.P., Mathur, B.N., Turner, C.A., Geske, R., Montgomery, C.A., Starbuck, M., Brandt, M., Gupta, A., Ramirez-Solis, R., Zambrowicz, B.P., Powell, D.R. Mol. Cell. Biol. (2001) [Pubmed]
  28. Murine Denys-Drash syndrome: evidence of podocyte de-differentiation and systemic mediation of glomerulosclerosis. Patek, C.E., Fleming, S., Miles, C.G., Bellamy, C.O., Ladomery, M., Spraggon, L., Mullins, J., Hastie, N.D., Hooper, M.L. Hum. Mol. Genet. (2003) [Pubmed]
  29. CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain. Shih, N.Y., Li, J., Cotran, R., Mundel, P., Miner, J.H., Shaw, A.S. Am. J. Pathol. (2001) [Pubmed]
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