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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DSC2  -  desmocollin 2

Canis lupus familiaris

 
 
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High impact information on DSC2

  • Desmosome formation occurred in two stages over 2 h, the first occurring within 30 min of the shift to HCM, in 60-nm vesicles containing chiefly Dsc2 and lower concentrations of Dsg and E-cadherin distributed to the entire cell surface [1].
  • A DSC2 clone isolated from a MDCK cDNA library had the same cell adhesion recognition sequence (Phe-Ala-Thr) as human, bovine and mouse type 2 isoforms [2].

References

  1. Desmosome assembly in MDCK cells: transport of precursors to the cell surface occurs by two phases of vesicular traffic and involves major changes in centrosome and Golgi location during a Ca(2+) shift. Burdett, I.D., Sullivan, K.H. Exp. Cell Res. (2002) [Pubmed]
  2. Antisense expression of a desmocollin gene in MDCK cells alters desmosome plaque assembly but does not affect desmoglein expression. Roberts, G.A., Burdett, I.D., Pidsley, S.C., King, I.A., Magee, A.I., Buxton, R.S. Eur. J. Cell Biol. (1998) [Pubmed]
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