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Gene Review

DSC2  -  desmocollin 2

Bos taurus

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Disease relevance of DSC2

  • The patient's serum showed reactivity with human desmocollin and was shown to react with bovine Dsc2 fusion protein, further suggesting the significance of anti-desmocollin autoantibodies in pemphigus [1].

High impact information on DSC2

  • DSC3 expression is strongly basal, DSC2 is strong in 5-10 suprabasal layers, and then weakens to be superseded by strong DSC1 [2].
  • DSC2 is ubiquitously expressed in epithelia and cardiac muscle [2].
  • Expression of glucose transporter 1 was significantly (P < 0.05) higher, and expression of desmocollin 2 and plakophilin tended to be higher (P < 0.1) for in vivo (group 4) compared with in vitro blastocysts (group 1), whereas no differences were found for heat shock protein 70.1, E-cadherin and poly(A) polymerase [3].


  1. A case of pemphigus vulgaris showing reactivity with pemphigus antigens (Dsg1 and Dsg3) and desmocollins. Hashimoto, T., Amagai, M., Watanabe, K., Dmochowski, M., Chidgey, M.A., Yue, K.K., Garrod, D.R., Nishikawa, T. J. Invest. Dermatol. (1995) [Pubmed]
  2. The bovine desmocollin family: a new gene and expression patterns reflecting epithelial cell proliferation and differentiation. Legan, P.K., Yue, K.K., Chidgey, M.A., Holton, J.L., Wilkinson, R.W., Garrod, D.R. J. Cell Biol. (1994) [Pubmed]
  3. Effects of oocyte maturation regimen on the relative abundance of gene transcripts in bovine blastocysts derived in vitro or in vivo. Knijn, H.M., Wrenzycki, C., Hendriksen, P.J., Vos, P.L., Herrmann, D., van der Weijden, G.C., Niemann, H., Dieleman, S.J. Reproduction (2002) [Pubmed]
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