Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

YY2 - YY2 transcription factor

Homo sapiens

Synonyms: Transcription factor YY2, YY-2, Yin and yang 2, ZNF631, Zinc finger protein 631

Luo, C. et al., Nguyen, N. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on YY2

A sequence analysis of this novel protein, YY2, revealed an overall 65% identity in the DNA sequence and a 56% identity in protein sequence compared with human YY1 [1].
Rapid evolution of a recently retroposed transcription factor YY2 in mammalian genomes [2].
Our results indicate that YY2 is a retroposed copy of YY1 that has been inserted into another gene locus named Mbtps2 (membrane-bound transcription factor protease site 2) [2].

Biological context of YY2

Similar to YY1, YY2 contains both transcriptional activation and repression functions [1].
YY2 was originally identified due to its unusual similarity to the evolutionarily well-conserved zinc finger gene YY1 [2].

Analytical, diagnostic and therapeutic context of YY2

Molecular cloning and functional characterization of the transcription factor YY2 [1].

References

Molecular cloning and functional characterization of the transcription factor YY2. Nguyen, N., Zhang, X., Olashaw, N., Seto, E. J. Biol. Chem. (2004) [Pubmed]
Rapid evolution of a recently retroposed transcription factor YY2 in mammalian genomes. Luo, C., Lu, X., Stubbs, L., Kim, J. Genomics (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

LOC102152457	Canis lupus familiaris
LOC696656	Macaca mulatta
Yy2	Mus musculus
YY2	Pan troglodytes

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.