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Gene Review

mael  -  maelstrom

Drosophila melanogaster

Synonyms: CG11254, Dmel\CG11254, MAEL, Mael, Protein maelstrom, ...
 
 
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High impact information on mael

  • By phenotypic characterization, we have defined maelstrom as a spindle-class gene that affects Vasa modification [1].
  • In a nuclear transport assay, we have determined that Maelstrom shuttles between the nucleus and cytoplasm, which may indicate a nuclear origin for nuage components [1].
  • maelstrom is required for an early step in the establishment of Drosophila oocyte polarity: posterior localization of grk mRNA [2].
  • We describe a mutant, maelstrom, that disrupts a previously unobserved step in mRNA localization within the early oocyte, distinct from nurse-cell-to-oocyte RNA transport [2].
  • Maelstrom is required to position the MTOC in stage 2-6 Drosophila oocytes [3].
 

Biological context of mael

  • The maelstrom gene encodes a novel protein that has a punctate distribution in the cytoplasm of the nurse cells and the oocyte until the protein disappears in stage 7 of oogenesis [2].
 

Anatomical context of mael

  • Here we present data that are consistent with the hypothesis that maelstrom is required for posterior positioning of the MTOC [3].

References

  1. Maelstrom, a Drosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage. Findley, S.D., Tamanaha, M., Clegg, N.J., Ruohola-Baker, H. Development (2003) [Pubmed]
  2. maelstrom is required for an early step in the establishment of Drosophila oocyte polarity: posterior localization of grk mRNA. Clegg, N.J., Frost, D.M., Larkin, M.K., Subrahmanyan, L., Bryant, Z., Ruohola-Baker, H. Development (1997) [Pubmed]
  3. Maelstrom is required to position the MTOC in stage 2-6 Drosophila oocytes. Clegg, N.J., Findley, S.D., Mahowald, A.P., Ruohola-Baker, H. Dev. Genes Evol. (2001) [Pubmed]
 
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