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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

RNA Transport

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Disease relevance of RNA Transport

  • Thus, REBP displays the characteristics expected of an authentic mediator of Rev NES function and may play a role in RRE RNA transport during HIV infection [1].

High impact information on RNA Transport


Biological context of RNA Transport

  • To investigate how protein kinases can overcome this problem and maintain both high substrate affinities and high turnover rates, the phosphorylation of the yeast RNA transport protein Npl3 by its natural protein kinase, Sky1p, was evaluated [7].
  • In contrast, the mutant hnRNP A1 binding site, or binding sites for hnRNP C and L are unable to stimulate Rev-mediated RNA transport [8].
  • Taken together, these data demonstrate that nuclear export can be determined by positively acting peptide motifs, namely, NESs, and suggest that Rev proteins activate viral RNA transport by providing export ribonucleoproteins with specific information that targets them to the cytoplasm [9].
  • Tip interacts with the RNA transport factor Tap, with signal transduction and activation of transcription factors, and with the T-cellular tyrosine kinase Lck, which is activated by this interaction and phosphorylates Tip as a substrate [10].

Anatomical context of RNA Transport


Associations of RNA Transport with chemical compounds

  • Inhibiting protein synthesis with cycloheximide did not disrupt the differential mRNA sorting, demonstrating that the differential targeting of mRNAs is not dependent on translation [16].
  • However, SM also contains a repetitive segment rich in arginine and proline residues that is dispensable for its effects on RNA transport and splicing [17].
  • In this study, the activities of two other NE-associated enzymes, protein phosphokinase and phosphoprotein phosphohydrolase, also implicated in nuclear RNA transport, were investigated in the livers of rats that received a single tube feeding of tryptophan [18].
  • Modulation of RNA transport by polyvinylpyrrolidone [19].
  • It is concluded that nuclear PLA(2) plays a regulatory role in RNA transport, which can be antagonized by exogenous PC [20].

Gene context of RNA Transport

  • We also show that RanBP1 interacts with the mammalian homolog of yeast protein RNA1, a protein involved in RNA transport and processing [21].
  • RTE-mediated RNA transport was CRM1 independent, and RTE did not show high affinity for binding to mRNA export factor TAP/NXF1 [22].
  • The conserved structural characteristics of the BICD1 protein and its expression in muscle and especially brain suggest that BICD1 is a component of a cytoskeleton-based mRNA sorting mechanism conserved during evolution [23].
  • In addition to its involvement with apobec-1 editosome, the suggested cellular functions of GRY-RBD and its structural homologues include RNA transport and RNA secondary structure stabilization [24].
  • These studies indicate that the RNA transport function of eIF4E could contribute to leukemogenesis [25].


  1. A nuclear kinesin-like protein interacts with and stimulates the activity of the leucine-rich nuclear export signal of the human immunodeficiency virus type 1 rev protein. Venkatesh, L.K., Gettemeier, T., Chinnadurai, G. J. Virol. (2003) [Pubmed]
  2. Diverse effects of the guanine nucleotide exchange factor RCC1 on RNA transport. Cheng, Y., Dahlberg, J.E., Lund, E. Science (1995) [Pubmed]
  3. Localization of ASH1 mRNA particles in living yeast. Bertrand, E., Chartrand, P., Schaefer, M., Shenoy, S.M., Singer, R.H., Long, R.M. Mol. Cell (1998) [Pubmed]
  4. In Saccharomyces cerevisiae, ATP2 mRNA sorting to the vicinity of mitochondria is essential for respiratory function. Margeot, A., Blugeon, C., Sylvestre, J., Vialette, S., Jacq, C., Corral-Debrinski, M. EMBO J. (2002) [Pubmed]
  5. Barentsz is essential for the posterior localization of oskar mRNA and colocalizes with it to the posterior pole. van Eeden, F.J., Palacios, I.M., Petronczki, M., Weston, M.J., St Johnston, D. J. Cell Biol. (2001) [Pubmed]
  6. Transport and localization elements in myelin basic protein mRNA. Ainger, K., Avossa, D., Diana, A.S., Barry, C., Barbarese, E., Carson, J.H. J. Cell Biol. (1997) [Pubmed]
  7. Chemical clamping allows for efficient phosphorylation of the RNA carrier protein Npl3. Aubol, B.E., Ungs, L., Lukasiewicz, R., Ghosh, G., Adams, J.A. J. Biol. Chem. (2004) [Pubmed]
  8. Synergistic stimulation of HIV-1 rev-dependent export of unspliced mRNA to the cytoplasm by hnRNP A1. Najera, I., Krieg, M., Karn, J. J. Mol. Biol. (1999) [Pubmed]
  9. Nuclear transport of human immunodeficiency virus type 1, visna virus, and equine infectious anemia virus Rev proteins: identification of a family of transferable nuclear export signals. Meyer, B.E., Meinkoth, J.L., Malim, M.H. J. Virol. (1996) [Pubmed]
  10. Herpesvirus saimiri. Fickenscher, H., Fleckenstein, B. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (2001) [Pubmed]
  11. Mechanisms of trafficking in axons and dendrites: implications for development and neurodegeneration. Sheetz, M.P., Pfister, K.K., Bulinski, J.C., Cotman, C.W. Prog. Neurobiol. (1998) [Pubmed]
  12. The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology. Fujii, R., Okabe, S., Urushido, T., Inoue, K., Yoshimura, A., Tachibana, T., Nishikawa, T., Hicks, G.G., Takumi, T. Curr. Biol. (2005) [Pubmed]
  13. Localization of nucleoside triphosphatase activity to the inner nuclear envelope and associated heterochromatin. Clawson, G.A., Friend, D.S., Smuckler, E.A. Exp. Cell Res. (1984) [Pubmed]
  14. RNA transport to the vegetal cortex of Xenopus oocytes. Zhou, Y., King, M.L. Dev. Biol. (1996) [Pubmed]
  15. Pur alpha protein implicated in dendritic RNA transport interacts with ribosomes in neuronal cytoplasm. Li, Y., Koike, K., Ohashi, S., Funakoshi, T., Tadano, M., Kobayashi, S., Anzai, K., Shibata, N., Kobayashi, M. Biol. Pharm. Bull. (2001) [Pubmed]
  16. Differential intracellular sorting of immediate early gene mRNAs depends on signals in the mRNA sequence. Wallace, C.S., Lyford, G.L., Worley, P.F., Steward, O. J. Neurosci. (1998) [Pubmed]
  17. Identification of a lytic-cycle Epstein-Barr virus gene product that can regulate PKR activation. Poppers, J., Mulvey, M., Perez, C., Khoo, D., Mohr, I. J. Virol. (2003) [Pubmed]
  18. Effect of tryptophan on enzymes and proteins of hepatic nuclear envelopes of rats. Murty, C.N., Hornseth, R., Verney, E., Sidransky, H. Lab. Invest. (1983) [Pubmed]
  19. Modulation of RNA transport by polyvinylpyrrolidone. Clawson, G.A., Button, J., Woo, C.H., Smuckler, E.A. Mol. Biol. Rep. (1984) [Pubmed]
  20. Phospholipase A2 inhibits nuclear nucleoside triphosphatase activity and mRNA export in isolated nuclei from rat liver. Li, J.X., Li, Z.Q., Pang, Y.Z., Tang, C.S. Life Sci. (2003) [Pubmed]
  21. Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing. Ren, M., Villamarin, A., Shih, A., Coutavas, E., Moore, M.S., LoCurcio, M., Clarke, V., Oppenheim, J.D., D'Eustachio, P., Rush, M.G. Mol. Cell. Biol. (1995) [Pubmed]
  22. Identification of a novel posttranscriptional regulatory element by using a rev- and RRE-mutated human immunodeficiency virus type 1 DNA proviral clone as a molecular trap. Nappi, F., Schneider, R., Zolotukhin, A., Smulevitch, S., Michalowski, D., Bear, J., Felber, B.K., Pavlakis, G.N. J. Virol. (2001) [Pubmed]
  23. A human homologue (BICD1) of the Drosophila bicaudal-D gene. Baens, M., Marynen, P. Genomics (1997) [Pubmed]
  24. Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome. Lau, P.P., Chang, B.H., Chan, L. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  25. Aberrant eukaryotic translation initiation factor 4E-dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis. Topisirovic, I., Guzman, M.L., McConnell, M.J., Licht, J.D., Culjkovic, B., Neering, S.J., Jordan, C.T., Borden, K.L. Mol. Cell. Biol. (2003) [Pubmed]
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