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Gene Review

SPoCk  -  Secretory Pathway Calcium atpase

Drosophila melanogaster

Synonyms: CG14449, CG32451, CG7651, Dmel\CG32451, SPoCK, ...
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High impact information on SPoCk

  • Interfering RNA directed against the common exons of the three SPoCk isoforms resulted in aberrant Ca2+ signaling and abolished neuropeptide-stimulated diuresis by the tubule [1].
  • It encoded three SPoCk isoforms with novel, distinct subcellular specificities in the endoplasmic reticulum (ER) and peroxisomes in addition to the Golgi [1].
  • Overexpression of organelle-specific SPoCk isoforms impacted on cytosolic Ca2+ handling in both cultured Drosophila cells and a transporting epithelium, the Drosophila Malpighian (renal) tubule [1].


  1. Novel subcellular locations and functions for secretory pathway Ca2+/Mn2+-ATPases. Southall, T.D., Terhzaz, S., Cabrero, P., Chintapalli, V.R., Evans, J.M., Dow, J.A., Davies, S.A. Physiol. Genomics (2006) [Pubmed]
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