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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Diuresis


Psychiatry related information on Diuresis


High impact information on Diuresis

  • Furthermore, the ANP neurons inhibit AVP release leading to diuresis and decreased ACTH release [11].
  • Responsiveness to hydralazine could not be restored by doubling the oral dose or by intravenous administration; tolerance was associated with fluid retention in five patients but was not reversed by intensive diuresis [12].
  • The normalization of serum sodium was secondary to osmotic diuresis and to sodium retention induced by urea [13].
  • Micropuncture was performed 6-10 hours after the fourth BNZ dose, when diuresis had subsided [14].
  • Rat inner medullary collecting ducts (IMCD3s) possess a luminal Na+-dependent, active urea secretory transport process, which is upregulated by water diuresis [15].

Chemical compound and disease context of Diuresis


Biological context of Diuresis


Anatomical context of Diuresis


Associations of Diuresis with chemical compounds

  • OPC-31260 increased the hypotonic urine volume dose dependently for the first 4 h, while furosemide induced sodium diuresis for 2 h [31].
  • Dopamine infusion in patients with ZGHP also enhanced (P less than 0.05) diuresis and natriuresis in comparison with normal-renin patients [32].
  • In order to assess the renal tubular site(s) at which sodium reabsorption is enhanced in chronic sodium-depletion, seven normal dogs, six salt-depleted dogs, and three normal dogs receiving aldosterone were studied during a steady-state water diuresis under Pentothal anesthesia and during progressive hypotonic saline diuresis [33].
  • It is concluded that high tubular fluid flow, whether induced by a solute or water diuresis, is the primary mechanism of protection in acute urate nephropathy [34].
  • Either meclofenamate (2 mg/kg) or the competitive prostaglandin inhibitor RO 20-5720 (1 mg/kg) was given to seven unanesthetized dogs undergoing a water diuresis [21].

Gene context of Diuresis

  • Whether postobstructive diuresis could be related to altered regulation of aquaporin (AQP) water channels in the kidney was investigated [35].
  • Pharmacologic inhibition of EP4 receptors in furosemide-treated WT mice with the specific antagonist ONO-AE3-208 mimicked the changes in renin mRNA expression, plasma renin concentration, diuresis, and sodium excretion seen in EP4-/- mice [36].
  • ANP causes diuresis and natriuresis, at least in part by inhibiting the V2 receptor-mediated action of AVP in the collecting ducts [37].
  • BACKGROUND: In a state of chronic arginine vasopressin (AVP) excess, the action of antidiuresis has been attenuated, resulting in some water diuresis [38].
  • We hypothesized that V2-receptor antagonism would yield a diuresis comparable to furosemide but would not adversely affect renal hemodynamics, plasma electrolyte concentration, or neurohumoral activation in stable human CHF [39].

Analytical, diagnostic and therapeutic context of Diuresis


  1. Control of ascites absorption in anesthetized cats: effects of intraperitoneal pressure, protein, and furosemide diuresis. Zink, J., Greenway, C.V. Gastroenterology (1977) [Pubmed]
  2. Natriuretic effect of an adenosine-1 receptor antagonist in cirrhotic patients with ascites. Stanley, A.J., Forrest, E.H., Dabos, K., Bouchier, I.A., Hayes, P.C. Gastroenterology (1998) [Pubmed]
  3. Administration of desmopressin in brain-dead donors and renal function in kidney recipients. Guesde, R., Barrou, B., Leblanc, I., Ourahma, S., Goarin, J.P., Coriat, P., Riou, B. Lancet (1998) [Pubmed]
  4. Renal hypoprostaglandism, hypertension, and type IV renal tubular acidosis reversed by furosemide. Sanjad, S.A., Keenan, B.S., Hill, L.L. Ann. Intern. Med. (1983) [Pubmed]
  5. Nephrotic syndrome: vasoconstriction and hypervolemic types indicated by renin-sodium profiling. Meltzer, J.I., Keim, H.J., Laragh, J.H., Sealey, J.E., Jan, K.M., Chien, S. Ann. Intern. Med. (1979) [Pubmed]
  6. The vasopressin and oxytocin neurons in the human supraoptic and paraventricular nucleus; changes with aging and in senile dementia. Fliers, E., Swaab, D.F., Pool, C.W., Verwer, R.W. Brain Res. (1985) [Pubmed]
  7. Sensitivity to the effects of a kappa opioid in rats with free access to exercise wheels: differential effects across behavioral measures. Smith, M.A., McClean, J.M., Bryant, P.A. Pharmacol. Biochem. Behav. (2004) [Pubmed]
  8. Inhibition of spontaneous or angiotensin II-stimulated water intake by atrial natriuretic factor. Masotto, C., Negro-Vilar, A. Brain Res. Bull. (1985) [Pubmed]
  9. Kappa opioid-induced diuresis in female vs. male rats. Craft, R.M., Ulibarri, C.M., Raub, D.J. Pharmacol. Biochem. Behav. (2000) [Pubmed]
  10. Distribution of de novo synthesized betaine in rat kidney: role of renal synthesis on medullary betaine accumulation. Moeckel, G.W., Lien, Y.H. Am. J. Physiol. (1997) [Pubmed]
  11. Atrial natriuretic peptide in brain and pituitary gland. Gutkowska, J., Antunes-Rodrigues, J., McCann, S.M. Physiol. Rev. (1997) [Pubmed]
  12. Hemodynamic characterization of tolerance to long-term hydralazine therapy in severe chronic heart failure. Packer, M., Meller, J., Medina, N., Yushak, M., Gorlin, R. N. Engl. J. Med. (1982) [Pubmed]
  13. Hyponatremia in the syndrome of inappropriate secretion of antidiuretic hormone. Rapid correction with urea, sodium chloride, and water restriction therapy. Decaux, G., Unger, J., Brimioulle, S., Mockel, J. JAMA (1982) [Pubmed]
  14. Temporal adjustment of the juxtaglomerular apparatus during sustained inhibition of proximal reabsorption. Thomson, S.C., Bachmann, S., Bostanjoglo, M., Ecelbarger, C.A., Peterson, O.W., Schwartz, D., Bao, D., Blantz, R.C. J. Clin. Invest. (1999) [Pubmed]
  15. Active sodium-urea counter-transport is inducible in the basolateral membrane of rat renal initial inner medullary collecting ducts. Kato, A., Sands, J.M. J. Clin. Invest. (1998) [Pubmed]
  16. Phase I study of thiotepa in combination with the glutathione transferase inhibitor ethacrynic acid. O'Dwyer, P.J., LaCreta, F., Nash, S., Tinsley, P.W., Schilder, R., Clapper, M.L., Tew, K.D., Panting, L., Litwin, S., Comis, R.L. Cancer Res. (1991) [Pubmed]
  17. Renin-angiotensin system in phlorhizin compared with alloxan diabetes in the rat. Christlieb, A.R., Long, R. Diabetes (1979) [Pubmed]
  18. Mannitol-induced acute renal failure. Visweswaran, P., Massin, E.K., Dubose, T.D. J. Am. Soc. Nephrol. (1997) [Pubmed]
  19. Effects of chronic, urea-induced osmotic diuresis on kidney weight and function in rats. Ogino, Y., Okada, S., Ota, Z. Diabetologia (1994) [Pubmed]
  20. "Renal dose" dopamine in surgical patients: dogma or science? Perdue, P.W., Balser, J.R., Lipsett, P.A., Breslow, M.J. Ann. Surg. (1998) [Pubmed]
  21. The effect of inhibition of prostaglandin synthesis on urinary sodium excretion in the conscious dog. Kirschenbaum, M.A., Stein, J.H. J. Clin. Invest. (1976) [Pubmed]
  22. Haemodynamic advantages of isosorbide dinitrate over frusemide in acute heart-failure following myocardial infarction. Nelson, G.I., Silke, B., Ahuja, R.C., Hussain, M., Taylor, S.H. Lancet (1983) [Pubmed]
  23. Dual inhibition of angiotensin-converting enzyme and neutral endopeptidase by the orally active inhibitor mixanpril: a potential therapeutic approach in hypertension. Fournié-Zaluski, M.C., Gonzalez, W., Turcaud, S., Pham, I., Roques, B.P., Michel, J.B. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  24. Atrial natriuretic factor stimulates Na/K/Cl cotransport in vascular smooth muscle cells. O'Donnell, M.E., Owen, N.E. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  25. Augmentation of renal blood flow and sodium excretion in hypertensive patients during blood pressure reduction by intravenous administration of the dopamine1 agonist fenoldopam. Murphy, M.B., McCoy, C.E., Weber, R.R., Frederickson, E.D., Douglas, F.L., Goldberg, L.I. Circulation (1987) [Pubmed]
  26. Mesna versus hyperhydration for the prevention of cyclophosphamide-induced hemorrhagic cystitis in bone marrow transplantation. Shepherd, J.D., Pringle, L.E., Barnett, M.J., Klingemann, H.G., Reece, D.E., Phillips, G.L. J. Clin. Oncol. (1991) [Pubmed]
  27. Plasma vasopressin during insulin withdrawal in insulin-dependent diabetes. Milles, J.J., Baylis, P.H., Wright, A.D. Diabetologia (1981) [Pubmed]
  28. The cytochrome P-450 inhibitor cobalt chloride prevents inhibition of renal Na,K-ATPase and redistribution of apical NHE-3 during acute hypertension. Zhang, Y.B., Magyar, C.E., Holstein-Rathlou, N.H., McDonough, A.A. J. Am. Soc. Nephrol. (1998) [Pubmed]
  29. Tissue concentration and urinary excretion pattern of sulfofluorescein by the rat kidney. Ammer, U., Natochin, Y., Ullrich, K.J. J. Am. Soc. Nephrol. (1993) [Pubmed]
  30. A nonpeptide mimic of bradykinin blunts the development of hypertension in young spontaneously hypertensive rats. Majima, M., Hayashi, I., Inamura, N., Fujita, T., Ogino, M. Hypertension (2000) [Pubmed]
  31. Potent aquaretic agent. A novel nonpeptide selective vasopressin 2 antagonist (OPC-31260) in men. Ohnishi, A., Orita, Y., Okahara, R., Fujihara, H., Inoue, T., Yamamura, Y., Yabuuchi, Y., Tanaka, T. J. Clin. Invest. (1993) [Pubmed]
  32. Aldosterone suppression with dopamine infusion in low-renin hypertension. Holland, O.B., Thomas, C., Brown, H., Schindewolf, D., Hillier, Y., Gomez-Sanchez, C. J. Clin. Invest. (1983) [Pubmed]
  33. Evidence for enhanced distal tubule sodium reabsorption in chronic salt-depleted dogs. Chou, S.Y., Ferder, L.F., Levin, D.L., Porush, J.G. J. Clin. Invest. (1976) [Pubmed]
  34. Intrarenal dynamics in the pathogenesis and prevention of acute urate nephropathy. Conger, J.D., Falk, S.A. J. Clin. Invest. (1977) [Pubmed]
  35. Diminished renal expression of aquaporin water channels in rats with experimental bilateral ureteral obstruction. Kim, S.W., Cho, S.H., Oh, B.S., Yeum, C.H., Choi, K.C., Ahn, K.Y., Lee, J. J. Am. Soc. Nephrol. (2001) [Pubmed]
  36. Dominant role of prostaglandin E2 EP4 receptor in furosemide-induced salt-losing tubulopathy: a model for hyperprostaglandin E syndrome/antenatal Bartter syndrome. Nüsing, R.M., Treude, A., Weissenberger, C., Jensen, B., Bek, M., Wagner, C., Narumiya, S., Seyberth, H.W. J. Am. Soc. Nephrol. (2005) [Pubmed]
  37. Physiological effects of vasopressin and atrial natriuretic peptide in the collecting duct. Inoue, T., Nonoguchi, H., Tomita, K. Cardiovasc. Res. (2001) [Pubmed]
  38. Role of aquaporin-2 gene expression in hyponatremic rats with chronic vasopressin-induced antidiuresis. Saito, T., Higashiyama, M., Nagasaka, S., Sasaki, S., Saito, T., Ishikawa, S.E. Kidney Int. (2001) [Pubmed]
  39. Vasopressin-2-receptor antagonism augments water excretion without changes in renal hemodynamics or sodium and potassium excretion in human heart failure. Costello-Boerrigter, L.C., Smith, W.B., Boerrigter, G., Ouyang, J., Zimmer, C.A., Orlandi, C., Burnett, J.C. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  40. Cross-circulation study of natriuretic factors in postobstructive diuresis. Wilson, D.R., Honrath, U. J. Clin. Invest. (1976) [Pubmed]
  41. Nephroprotection by theophylline in patients with cisplatin chemotherapy: a randomized, single-blinded, placebo-controlled trial. Benoehr, P., Krueth, P., Bokemeyer, C., Grenz, A., Osswald, H., Hartmann, J.T. J. Am. Soc. Nephrol. (2005) [Pubmed]
  42. 'Low sodium' diuresis and ileal loss in patients with ileostomies: effect of desmopressin. Sutters, M., Carmichael, D.J., Unwin, R.J., Sozi, C., Hunter, M., Calam, J., Lightman, S.L., Peart, W.S. Gut (1991) [Pubmed]
  43. Sustained improvement in functional capacity after removal of body fluid with isolated ultrafiltration in chronic cardiac insufficiency: failure of furosemide to provide the same result. Agostoni, P., Marenzi, G., Lauri, G., Perego, G., Schianni, M., Sganzerla, P., Guazzi, M.D. Am. J. Med. (1994) [Pubmed]
  44. Regulation of aldose reductase, sorbitol dehydrogenase, and taurine cotransporter mRNA in rat medulla. Martial, S., Price, S.R., Sands, J.M. J. Am. Soc. Nephrol. (1995) [Pubmed]
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