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Gene Review

Atp2c1  -  ATPase, Ca++-sequestering

Mus musculus

Synonyms: 1700121J11Rik, ATP-dependent Ca(2+) pump PMR1, ATP2C1A, ATPase 2C1, AW061228, ...
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Disease relevance of Atp2c1

  • In BALB/c and in transgenic HHD mice for human HLA-A2 class I, both vectors are efficient immunogens and induced broad cellular immune responses against peptides represented in the four HIV-1 antigens [1].
  • In DNA prime/poxvirus boost protocols, the strongest immune response, as measured by fresh IFN-gamma and IL-2 ELISPOT, was obtained in BALB/c mice boosted with NYVAC-B, while in HHD mice there were no differences between the poxvirus vectors [1].

High impact information on Atp2c1

  • In contrast to mHER-2(9(435)), vaccination of HLA-A*0201 transgenic (HHD) mice with hHER-2(9(435)) significantly increased the frequency of mHER-2(9(435))-specific CTL and also induced strong protective and therapeutic immunity against the transplantable ALC tumor cell line transfected to coexpress HLA-A*0201 and hHER-2/neu or rHER-2/neu [2].
  • Peptide specific murine CD8 T cells recognized COS-7 cells co-transfected with HHD (HLA-A*0201) and STEAP cDNA constructs and also HLA-A*0201(+) STEAP(+) human tumor cells [3].


  1. Head-to-head comparison on the immunogenicity of two HIV/AIDS vaccine candidates based on the attenuated poxvirus strains MVA and NYVAC co-expressing in a single locus the HIV-1(BX08) gp120 and HIV-1(IIIB) Gag-Pol-Nef proteins of clade B. Gómez, C.E., Nájera, J.L., Jiménez, E.P., Jiménez, V., Wagner, R., Graf, M., Frachette, M.J., Liljeström, P., Pantaleo, G., Esteban, M. Vaccine (2007) [Pubmed]
  2. Vaccination with human HER-2/neu (435-443) CTL peptide induces effective antitumor immunity against HER-2/neu-expressing tumor cells in vivo. Gritzapis, A.D., Mahaira, L.G., Perez, S.A., Cacoullos, N.T., Papamichail, M., Baxevanis, C.N. Cancer Res. (2006) [Pubmed]
  3. STEAP, a prostate tumor antigen, is a target of human CD8(+) T cells. Alves, P.M., Faure, O., Graff-Dubois, S., Cornet, S., Bolonakis, I., Gross, D.A., Miconnet, I., Chouaib, S., Fizazi, K., Soria, J.C., Lemonnier, F.A., Kosmatopoulos, K. Cancer Immunol. Immunother. (2006) [Pubmed]
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