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Gene Review:

LOC406142 - hymenoptaecin

Apis mellifera

Kucharski, R. et al., Casteels, P. et al.

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Disease relevance of LOC406142

We show that a transcriptional response of transferrin to septic injury with E. coli is relatively moderate as compared to a dramatic up-regulation of an antibacterial polypeptide, Hymenoptaecin, under similar conditions [1].

High impact information on LOC406142

In addition to the previously characterized apidaecins and abaecin, we also isolated a member of the defensin family of peptide antibiotics and, now, a novel 93-amino acid long, cationic polypeptide, termed hymenoptaecin [2].

References

Transcriptional profiling reveals multifunctional roles for transferrin in the honeybee, Apis mellifera. Kucharski, R., Maleszka, R. J. Insect Sci. (2003) [Pubmed]
Functional and chemical characterization of Hymenoptaecin, an antibacterial polypeptide that is infection-inducible in the honeybee (Apis mellifera). Casteels, P., Ampe, C., Jacobs, F., Tempst, P. J. Biol. Chem. (1993) [Pubmed]

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