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Gene Review

LOC406144  -  abaecin

Apis mellifera

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Disease relevance of LOC406144


High impact information on LOC406144

  • In addition to the previously characterized apidaecins and abaecin, we also isolated a member of the defensin family of peptide antibiotics and, now, a novel 93-amino acid long, cationic polypeptide, termed hymenoptaecin [2].
  • The primary structure and antibacterial character of the novel peptides resemble those of abaecin (41% identity in amino acid sequence), an antibacterial peptide of the honeybee, although abaecin is not O-glycosylated [3].
  • A humoral immune response of bees parasitized by V. destructor may be detected by studying the expression levels of antibacterial peptides, such as abaecin and defensin, known to be immune-responsive [4].
  • One of these genes, abaecin, shows significant up-regulation 24 h following oral inoculation with P. larvae, precisely when the bacterium surmounts the midgut epithelia of bees [5].


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