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Gene Review

Tsf1  -  transferrin 1

Apis mellifera

Synonyms: GB19745, Trf
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Disease relevance of Trf

  • We show that a transcriptional response of transferrin to septic injury with E. coli is relatively moderate as compared to a dramatic up-regulation of an antibacterial polypeptide, Hymenoptaecin, under similar conditions [1].
  • The show that the expression of vitellogenin and transferrin is correlated with ovary activation in workers, and may therefore be part of the gene network involved in the regulatory control of functional sterility in honeybees [2].

High impact information on Trf

  • Social life is prone to invasion by microorganisms, and binding of ferric ions by transferrin is an efficient strategy to restrict their access to iron [3].
  • Vitellogenin, an egg yolk precursor, and transferrin, an iron transporter, were two transcripts found to be significantly down-regulated as a function of the ovary-inhibiting treatment [2].


  1. Transcriptional profiling reveals multifunctional roles for transferrin in the honeybee, Apis mellifera. Kucharski, R., Maleszka, R. J. Insect Sci. (2003) [Pubmed]
  2. Effects of carbon dioxide narcosis on ovary activation and gene expression in worker honeybees, Apis mellifera. Koywiwattrakul, P., Thompson, G.J., Sitthipraneed, S., Oldroyd, B.P., Maleszka, R. J. Insect Sci. (2005) [Pubmed]
  3. Honey bee (Apis mellifera) transferrin-gene structure and the role of ecdysteroids in the developmental regulation of its expression. do Nascimento, A.M., Cuvillier-Hot, V., Barchuk, A.R., Simões, Z.L., Hartfelder, K. Insect Biochem. Mol. Biol. (2004) [Pubmed]
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