The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

Def1  -  defensin 1

Apis mellifera

Synonyms: Def, GB19392
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Def

  • With the aim of studying the evolution of immune system genes, we identified a gene encoding the antimicrobial peptide defensin from a social insect, the wood ant Formica aquilonia [1].
  • The ant defensin gene structure differs from both of these bee defensins with respect to the number and length of introns and exons [1].
  • Mature defensin 2 peptide shows 55.8% identity with defensin 1 [2].
  • Two defensins showing high mutual similarity have previously been characterized in honeybee Apis mellifera: royalisin, a peptide isolated from the royal jelly, and defensin, found in the hemolymph of bacterially infected bees [2].
  • Immune response elements were identified by computer analysis of the promoter regions of defensin genes [2].

Other interactions of Def

  • A humoral immune response of bees parasitized by V. destructor may be detected by studying the expression levels of antibacterial peptides, such as abaecin and defensin, known to be immune-responsive [3].

Analytical, diagnostic and therapeutic context of Def

  • Transcription of defensin genes in some nurse honeybees tissues was studied by RT-PCR [2].


  1. Identification and molecular characterization of defensin gene from the ant Formica aquilonia. Viljakainen, L., Pamilo, P. Insect Mol. Biol. (2005) [Pubmed]
  2. Two structurally different defensin genes, one of them encoding a novel defensin isoform, are expressed in honeybee Apis mellifera. Klaudiny, J., Albert, S., Bachanová, K., Kopernický, J., Simúth, J. Insect Biochem. Mol. Biol. (2005) [Pubmed]
  3. Conditional immune-gene suppression of honeybees parasitized by Varroa mites. Gregory, P.G., Evans, J.D., Rinderer, T., de Guzman, L. J. Insect Sci. (2005) [Pubmed]
WikiGenes - Universities