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Gene Review

ALS7  -  amyotrophic lateral sclerosis 7

Homo sapiens

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High impact information on ALS7

  • ORFs in the opposite direction contained within the ALS7 ORF were also transcribed in all strains tested [1].
  • C. albicans is diploid, and combinations of ALS7 alleles generated 49 different genotypes [1].
  • Detection of transcripts from ALS7, and particularly from ALS6, was more sporadic, but not associated with a strictly temporal pattern [2].
  • Expression of all ALS genes was observed in oral clinical material collected from HIV-positive patients although ALS6 and ALS7 transcripts required an extra PCR amplification step to be detected [3].


  1. Sixty alleles of the ALS7 open reading frame in Candida albicans: ALS7 is a hypermutable contingency locus. Zhang, N., Harrex, A.L., Holland, B.R., Fenton, L.E., Cannon, R.D., Schmid, J. Genome Res. (2003) [Pubmed]
  2. RT-PCR detection of Candida albicans ALS gene expression in the reconstituted human epithelium (RHE) model of oral candidiasis and in model biofilms. Green, C.B., Cheng, G., Chandra, J., Mukherjee, P., Ghannoum, M.A., Hoyer, L.L. Microbiology (Reading, Engl.) (2004) [Pubmed]
  3. RT-PCR analysis of Candida albicans ALS gene expression in a hyposalivatory rat model of oral candidiasis and in HIV-positive human patients. Green, C.B., Marretta, S.M., Cheng, G., Faddoul, F.F., Ehrhart, E.J., Hoyer, L.L. Med. Mycol. (2006) [Pubmed]
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