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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ncor2  -  nuclear receptor corepressor 2

Xenopus laevis

 
 
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High impact information on SMRT

  • We found that TBLR1, SMRT, and N-CoR are recruited to T(3)-inducible promoters in premetamorphic tadpoles and are released upon T(3) treatment, which induces metamorphosis [1].
  • These experiments indicate a critical role for the alternative splicing of SMRT in development [2].
  • The corepressor SMRT acts on a range of transcription factors, including the retinoid and thyroid hormone nuclear receptors [2].

References

  1. Recruitment of N-CoR/SMRT-TBLR1 corepressor complex by unliganded thyroid hormone receptor for gene repression during frog development. Tomita, A., Buchholz, D.R., Shi, Y.B. Mol. Cell. Biol. (2004) [Pubmed]
  2. Xenopus embryos lacking specific isoforms of the corepressor SMRT develop abnormal heads. Malartre, M., Short, S., Sharpe, C. Dev. Biol. (2006) [Pubmed]
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