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Gene Review:

Ama - Amalgam

Drosophila melanogaster

Synonyms: AMA, BG:DS00276.6, CG2198, CT7244, Dmel\CG2198, ...

Liebl, E.C. et al., Frémion, F. et al.

Liebl, Rowe, Forsthoefel, Stammler, Schmidt, Turski, Seeger,

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High impact information on Ama

Furthermore, AMA is necessary for NRT-expressing cells both to aggregate with themselves and to associate with embryonic primary culture cells [1].

Biological context of Ama

Cell culture experiments demonstrate the Ama(M109) mutant protein binds to Nrt, but is defective in mediating Ama/Nrt cell adhesion [2].

Associations of Ama with chemical compounds

Interactions between the secreted protein Amalgam, its transmembrane receptor Neurotactin and the Abelson tyrosine kinase affect axon pathfinding [2].

Other interactions of Ama

Amalgam (Ama) is a secreted protein that interacts with the transmembrane protein Neurotactin (Nrt) to promote cell:cell adhesion [2].

References

Amalgam is a ligand for the transmembrane receptor neurotactin and is required for neurotactin-mediated cell adhesion and axon fasciculation in Drosophila. Frémion, F., Darboux, I., Diano, M., Hipeau-Jacquotte, R., Seeger, M.A., Piovant, M. EMBO J. (2000) [Pubmed]
Interactions between the secreted protein Amalgam, its transmembrane receptor Neurotactin and the Abelson tyrosine kinase affect axon pathfinding. Liebl, E.C., Rowe, R.G., Forsthoefel, D.J., Stammler, A.L., Schmidt, E.R., Turski, M., Seeger, M.A. Development (2003) [Pubmed]

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