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Gene Review:

nac - neuronally altered carbohydrate

Drosophila melanogaster

Synonyms: CG9620, Dmel\CG9620, GDP-fucose transporter 1, Gfr, Neuronally altered carbohydrate, ...

Ishikawa, H.O. et al., Lühn, K. et al.

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High impact information on Gfr

Our phenotype analyses revealed that Notch (N) signaling was deficient in these Gfr mutants [1].
Biochemically, we demonstrated that a Drosophila homolog of the GDP-fucose transporter, the Golgi GDP-fucose transporter (Gfr), specifically transports GDP-fucose in vitro [1].
Finally, we found that mammalian Gfr is required for N signaling in mammalian cultured cells [1].
The phenotypes of the Drosophila Gfr mutants were rescued by the human GDP-fucose transporter transgene [1].
However, despite the essential role of N O-fucosylation during development, the Gfr homozygote was viable [1].

Biological context of Gfr

We show that transient transfection of these cells with the Drosophila CG9620 cDNA corrects the GDP-fucose transport defect and reestablishes fucosylation [2].

References

Notch deficiency implicated in the pathogenesis of congenital disorder of glycosylation IIc. Ishikawa, H.O., Higashi, S., Ayukawa, T., Sasamura, T., Kitagawa, M., Harigaya, K., Aoki, K., Ishida, N., Sanai, Y., Matsuno, K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
Identification and molecular cloning of a functional GDP-fucose transporter in Drosophila melanogaster. Lühn, K., Laskowska, A., Pielage, J., Klämbt, C., Ipe, U., Vestweber, D., Wild, M.K. Exp. Cell Res. (2004) [Pubmed]

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