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Gene Review:

MAGEA11 - melanoma antigen family A, 11

Homo sapiens

Synonyms: CT1.11, Cancer/testis antigen 1.11, MAGE-11, MAGE-11 antigen, MAGE11, ...

Bai, S. et al., Jurk, M. et al.

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Disease relevance of MAGEA11

MAGE-11 is expressed in androgen-dependent tissues and in prostate cancer cell lines [1].

High impact information on MAGEA11

Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction [1].
In contrast to other known proteins of the MAGE family, MAGE-11 is found mainly in the nucleus [2].

Other interactions of MAGEA11

Intracellular association between AR and MAGE-11 is supported by their coimmunoprecipitation and colocalization in the absence and presence of hormone and by competitive inhibition of the N/C interaction [1].

Analytical, diagnostic and therapeutic context of MAGEA11

Immunoprecipitation out of whole-cell extracts from different species reveals that MAGE-11 protein is highly conserved among mammalian cells, suggesting a conserved and important function [2].

References

Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction. Bai, S., He, B., Wilson, E.M. Mol. Cell. Biol. (2005) [Pubmed]
MAGE-11 protein is highly conserved in higher organisms and located predominantly in the nucleus. Jurk, M., Kremmer, E., Schwarz, U., Förster, R., Winnacker, E.L. Int. J. Cancer (1998) [Pubmed]

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MAGEA11	Macaca mulatta
Magea4	Mus musculus
LOC465899	Pan troglodytes
Magea4	Rattus norvegicus

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