Gene Review:
AR - androgen receptor
Homo sapiens
Synonyms:
AIS, Androgen receptor, DHTR, Dihydrotestosterone receptor, HUMARA, ...
Vorreuther,
Vidaud,
Solleder,
Buettner,
Gullotti,
Culig,
De Vos,
Nelson,
Bartsch,
Heukamp,
Metzger,
Van Pottelbergh,
T'Sjoen,
Latil,
Cussenot,
Steiner,
Wolf,
Bastian,
Berthon,
Vidaud,
Kahl,
Goemaere,
Coetzee,
Mulholland,
Friedrichs,
Dierick,
Hobisch,
Van Heeringen,
Ellinger,
Bièche,
Wilson,
Sch??le,
Kaufman,
Lidereau,
Dedhar,
- Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking. Wang, Q., Carroll, J.S., Brown, M. Mol. Cell (2005)
- Human megakaryocytes and platelets contain the estrogen receptor beta and androgen receptor (AR): testosterone regulates AR expression. Khetawat, G., Faraday, N., Nealen, M.L., Vijayan, K.V., Bolton, E., Noga, S.J., Bray, P.F. Blood (2000)
- Medroxyprogesterone acetate therapy in advanced breast cancer: the predictive value of androgen receptor expression. Birrell, S.N., Roder, D.M., Horsfall, D.J., Bentel, J.M., Tilley, W.D. J. Clin. Oncol. (1995)
- Specificity of cyclin D1 for androgen receptor regulation. Petre-Draviam, C.E., Cook, S.L., Burd, C.J., Marshall, T.W., Wetherill, Y.B., Knudsen, K.E. Cancer Res. (2003)
- BRCA2 germ-line mutations are frequent in male breast cancer patients without a family history of the disease. Haraldsson, K., Loman, N., Zhang, Q.X., Johannsson, O., Olsson, H., Borg, A. Cancer Res. (1998)
- Sex steroid level, androgen receptor polymorphism, and depressive symptoms in healthy elderly men. T'Sjoen, G.G., De Vos, S., Goemaere, S., Van Pottelbergh, I., Dierick, M., Van Heeringen, C., Kaufman, J.M. Journal of the American Geriatrics Society. (2005)
- Androgens, androgen receptors, and male gender role behavior. Wilson, J.D. Hormones and behavior. (2001)
- Prostate specific antigen expression is down-regulated by selenium through disruption of androgen receptor signaling. Dong, Y., Lee, S.O., Zhang, H., Marshall, J., Gao, A.C., Ip, C. Cancer Res. (2004)
- Association study of androgen receptor CAG repeat polymorphism and male violent criminal activity. Cheng, D., Hong, C.J., Liao, D.L., Tsai, S.J. Psychoneuroendocrinology (2006)
- Sex steroid-related genes and male-to-female transsexualism. Henningsson, S., Westberg, L., Nilsson, S., Lundström, B., Ekselius, L., Bodlund, O., Lindström, E., Hellstrand, M., Rosmond, R., Eriksson, E., Landén, M. Psychoneuroendocrinology (2005)
- Advances in prostate cancer chemotherapy: a new era begins. Pienta, K.J., Smith, D.C. CA: a cancer journal for clinicians. (2005)
- Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Kousteni, S., Bellido, T., Plotkin, L.I., O'Brien, C.A., Bodenner, D.L., Han, L., Han, K., DiGregorio, G.B., Katzenellenbogen, J.A., Katzenellenbogen, B.S., Roberson, P.K., Weinstein, R.S., Jilka, R.L., Manolagas, S.C. Cell (2001)
- Monoclonal origin of multicentric Kaposi's sarcoma lesions. Rabkin, C.S., Janz, S., Lash, A., Coleman, A.E., Musaba, E., Liotta, L., Biggar, R.J., Zhuang, Z. N. Engl. J. Med. (1997)
- Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer. Taplin, M.E., Bubley, G.J., Shuster, T.D., Frantz, M.E., Spooner, A.E., Ogata, G.K., Keer, H.N., Balk, S.P. N. Engl. J. Med. (1995)
- Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. Yeh, S., Chang, C. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Decreased androgen receptor levels and receptor function in breast cancer contribute to the failure of response to medroxyprogesterone acetate. Buchanan, G., Birrell, S.N., Peters, A.A., Bianco-Miotto, T., Ramsay, K., Cops, E.J., Yang, M., Harris, J.M., Simila, H.A., Moore, N.L., Bentel, J.M., Ricciardelli, C., Horsfall, D.J., Butler, L.M., Tilley, W.D. Cancer Res. (2005)
- The use of phage display technique for the isolation of androgen receptor interacting peptides with (F/W)XXL(F/W) and FXXLY new signature motifs. Hsu, C.L., Chen, Y.L., Yeh, S., Ting, H.J., Hu, Y.C., Lin, H., Wang, X., Chang, C. J. Biol. Chem. (2003)
- Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know? Mulholland, D.J., Dedhar, S., Coetzee, G.A., Nelson, C.C. Endocr. Rev. (2005)
- Hormonal markers and hepatitis B virus-related hepatocellular carcinoma risk: a nested case-control study among men. Yu, M.W., Yang, Y.C., Yang, S.Y., Cheng, S.W., Liaw, Y.F., Lin, S.M., Chen, C.J. J. Natl. Cancer Inst. (2001)
- hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci. Sharma, M., Li, X., Wang, Y., Zarnegar, M., Huang, C.Y., Palvimo, J.J., Lim, B., Sun, Z. EMBO J. (2003)
- Supervillin associates with androgen receptor and modulates its transcriptional activity. Ting, H.J., Yeh, S., Nishimura, K., Chang, C. Proc. Natl. Acad. Sci. U.S.A. (2002)
- A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer. Metzger, E., Müller, J.M., Ferrari, S., Buettner, R., Schüle, R. EMBO J. (2003)
- FHL2, a novel tissue-specific coactivator of the androgen receptor. Müller, J.M., Isele, U., Metzger, E., Rempel, A., Moser, M., Pscherer, A., Breyer, T., Holubarsch, C., Buettner, R., Schüle, R. EMBO J. (2000)
- From estrogen to androgen receptor: a new pathway for sex hormones in prostate. Yeh, S., Miyamoto, H., Shima, H., Chang, C. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function. Fu, M., Wang, C., Wang, J., Zhang, X., Sakamaki, T., Yeung, Y.G., Chang, C., Hopp, T., Fuqua, S.A., Jaffray, E., Hay, R.T., Palvimo, J.J., Jänne, O.A., Pestell, R.G. Mol. Cell. Biol. (2002)
- Activation of the DNA-dependent protein kinase stimulates nuclear export of the androgen receptor in vitro. Shank, L.C., Kelley, J.B., Gioeli, D., Yang, C.S., Spencer, A., Allison, L.A., Paschal, B.M. J. Biol. Chem. (2008)
- Cyclin-dependent kinase 6 associates with the androgen receptor and enhances its transcriptional activity in prostate cancer cells. Lim, J.T., Mansukhani, M., Weinstein, I.B. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Androgen Receptor Coactivators Lysine-Specific Histone Demethylase 1 and Four and a Half LIM Domain Protein 2 Predict Risk of Prostate Cancer Recurrence. Kahl, P., Gullotti, L., Heukamp, L.C., Wolf, S., Friedrichs, N., Vorreuther, R., Solleder, G., Bastian, P.J., Ellinger, J., Metzger, E., Sch??le, R., Buettner, R. Cancer Res. (2006)
- CREB binding protein is a coactivator for the androgen receptor and mediates cross-talk with AP-1. Frønsdal, K., Engedal, N., Slagsvold, T., Saatcioglu, F. J. Biol. Chem. (1998)
- Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate. Fujimoto, N., Yeh, S., Kang, H.Y., Inui, S., Chang, H.C., Mizokami, A., Chang, C. J. Biol. Chem. (1999)
- The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists. Hodgson, M.C., Astapova, I., Cheng, S., Lee, L.J., Verhoeven, M.C., Choi, E., Balk, S.P., Hollenberg, A.N. J. Biol. Chem. (2005)
- Mechanisms of endocrine therapy-responsive and -unresponsive prostate tumours. Culig, Z., Steiner, H., Bartsch, G., Hobisch, A. Endocr. Relat. Cancer (2005)
- Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A. Li, L., Ren, C.H., Tahir, S.A., Ren, C., Thompson, T.C. Mol. Cell. Biol. (2003)
- Inhibition of androgen receptor-mediated transcription by amino-terminal enhancer of split. Yu, X., Li, P., Roeder, R.G., Wang, Z. Mol. Cell. Biol. (2001)
- Glycogen synthase kinase-3 beta is involved in the phosphorylation and suppression of androgen receptor activity. Salas, T.R., Kim, J., Vakar-Lopez, F., Sabichi, A.L., Troncoso, P., Jenster, G., Kikuchi, A., Chen, S.Y., Shemshedini, L., Suraokar, M., Logothetis, C.J., DiGiovanni, J., Lippman, S.M., Menter, D.G. J. Biol. Chem. (2004)
- Functional analysis of a novel androgen receptor mutation, Q902K, in an individual with partial androgen insensitivity. Umar, A., Berrevoets, C.A., Van, N.M., van Leeuwen, M., Verbiest, M., Kleijer, W.J., Dooijes, D., Grootegoed, J.A., Drop, S.L., Brinkmann, A.O. J. Clin. Endocrinol. Metab. (2005)
- Filamin-A fragment localizes to the nucleus to regulate androgen receptor and coactivator functions. Loy, C.J., Sim, K.S., Yong, E.L. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Thyroid receptor activator molecule, TRAM-1, is an androgen receptor coactivator. Tan, J.A., Hall, S.H., Petrusz, P., French, F.S. Endocrinology (2000)
- Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Wissmann, M., Yin, N., Müller, J.M., Greschik, H., Fodor, B.D., Jenuwein, T., Vogler, C., Schneider, R., Günther, T., Buettner, R., Metzger, E., Schüle, R. Nat. Cell Biol. (2007)
- Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation. Burd, C.J., Petre, C.E., Morey, L.M., Wang, Y., Revelo, M.P., Haiman, C.A., Lu, S., Fenoglio-Preiser, C.M., Li, J., Knudsen, E.S., Wong, J., Knudsen, K.E. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Expression of human estrogen receptor-alpha and -beta, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells. Lau, K.M., Mok, S.C., Ho, S.M. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Evaluation of androgen, estrogen (ER alpha and ER beta), and progesterone receptor expression in human prostate cancer by real-time quantitative reverse transcription-polymerase chain reaction assays. Latil, A., Bièche, I., Vidaud, D., Lidereau, R., Berthon, P., Cussenot, O., Vidaud, M. Cancer Res. (2001)
- A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4. Amir, A.L., Barua, M., McKnight, N.C., Cheng, S., Yuan, X., Balk, S.P. J. Biol. Chem. (2003)
- Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA. Yeap, B.B., Voon, D.C., Vivian, J.P., McCulloch, R.K., Thomson, A.M., Giles, K.M., Czyzyk-Krzeska, M.F., Furneaux, H., Wilce, M.C., Wilce, J.A., Leedman, P.J. J. Biol. Chem. (2002)