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Gene Review

COMT  -  catechol-O-methyltransferase

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High impact information on COMT

  • The applicability of the method was demonstrated by the characterization of COMT activity-time courses in human erythrocytes after oral administration of the COMT inhibitor tolcapone [1].
  • The method is based on the COMT-mediated O-methylation of 4-(naphtho [1,2-d] thiazol-2-yl) pyrocatechol, the product of which was determined fluorometrically [1].
  • The relative rate of different routes of disposition of catecholamines was in the following order: for (-)-NE COMT greater than or equal to MAO greater than or equal to U2 greater than U1, for (-)-Epi U2 greater than or equal to COMT greater than MAO greater than U1 [2].


  1. Assessment of catechol-O-methyltransferase activity and its inhibition in erythrocytes of animals and humans. Zürcher, G., Da Prada, M., Dingemanse, J. Biomed. Chromatogr. (1996) [Pubmed]
  2. Disposition of norepinephrine and epinephrine in jejunum of WLH chicken. Punia, J.S., Garg, B.D. Indian J. Exp. Biol. (1992) [Pubmed]
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