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Gene Review

Comt  -  catechol-O-methyltransferase

Rattus norvegicus

Synonyms: Catechol O-methyltransferase
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Disease relevance of Comt


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Chemical compound and disease context of Comt


Biological context of Comt


Anatomical context of Comt


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Regulatory relationships of Comt


Other interactions of Comt


Analytical, diagnostic and therapeutic context of Comt


  1. Reduced membrane-bound catechol-O-methyltransferase in the liver of spontaneously hypertensive rats. Tsunoda, M., Tenhunen, J., Tilgmann, C., Arai, H., Imai, K. Hypertens. Res. (2003) [Pubmed]
  2. Sensitization to the generalized Shwartzman reaction by catechol-O-methyltransferase inhibitors. Latour, J.G., Láger-Gauthier, C. Am. J. Pathol. (1978) [Pubmed]
  3. Expression of differentiated activities in reaggregated brain cell cultures. Seeds, N.W. J. Biol. Chem. (1975) [Pubmed]
  4. Monoamine oxidase and catechol-O-methyltransferase activity in hamster and rat insulinomas. Feldman, J.M., Reintgen, D.S., Seigler, H.F. Diabetologia (1979) [Pubmed]
  5. Catechol-O-methyltransferase inhibition attenuates levodopa toxicity in mesencephalic dopamine neurons. Storch, A., Blessing, H., Bareiss, M., Jankowski, S., Ling, Z.D., Carvey, P., Schwarz, J. Mol. Pharmacol. (2000) [Pubmed]
  6. Tolcapone, an inhibitor of catechol O-methyltransferase, counteracts memory deficits caused by bilateral cholinotoxin lesions of the basal nuclei of Meynert. Khromova, I., Rauhala, P., Zolotov, N., Männistö, P.T. Neuroreport (1995) [Pubmed]
  7. Beneficial effects of co-administration of catechol-O-methyltransferase inhibitors and L-dihydroxyphenylalanine in rat models of depression. Männistö, P.T., Lang, A., Rauhala, P., Vasar, E. Eur. J. Pharmacol. (1995) [Pubmed]
  8. Role of a non-ionic detergent upon maintenance and radioisotopic determination of enzymes catechol-O-methyltransferase and monoamine oxidase in brain and adrenal tissues. Chaudhuri, S., Parvez, H., Marzouki, L., Parvez, S. Journal de pharmacologie. (1982) [Pubmed]
  9. Cardiac epinephrine synthesis. Regulation by a glucocorticoid. Kennedy, B., Ziegler, M.G. Circulation (1991) [Pubmed]
  10. Altered norepinephrine turnover and metabolism in diabetic cardiomyopathy. Ganguly, P.K., Dhalla, K.S., Innes, I.R., Beamish, R.E., Dhalla, N.S. Circ. Res. (1986) [Pubmed]
  11. Radiochemical detection of dihydrodiol dehydrogenase: distribution of the enzyme in male Sprague-Dawley rat tissues and its sensitivity to inhibition by indomethacin and 6-medroxyprogesterone acetate. Ivins, J.K., Penning, T.M. Cancer Res. (1987) [Pubmed]
  12. 3-O-methyldopa blocks dopa metabolism in rat corpus striatum. Reches, A., Fahn, S. Ann. Neurol. (1982) [Pubmed]
  13. Enzymatic methylation of microsomal metabolites of benzo(a)pyrene. Lombardi, P.E., Mayhew, J.W., Goldin, B.R., Gregory, M.E., Lynch, M.A., Sullivan, C.E., Gorbach, S.L. Cancer Res. (1981) [Pubmed]
  14. Metabolism and storage of catecholamines in rats with pheochromocytoma implants. Buu, N.T., Kuchel, O., Manger, W., Hulse, M.C., Chute, R.N. Hypertension (1986) [Pubmed]
  15. Catechol-O-methyltransferase inhibition protects against 3,4-dihydroxyphenylalanine (DOPA) toxicity in primary mesencephalic cultures: new insights into levodopa toxicity. Blessing, H., Bareiss, M., Zettlmeisl, H., Schwarz, J., Storch, A. Neurochem. Int. (2003) [Pubmed]
  16. Impairment of the extraneuronal O-methylating system of isoproterenol by stop-flow ischemia in the perfused rat heart. Inoue, M., Hifumi, K., Kurahashi, K., Fujiwara, M. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  17. Pyridoxine 5'-phosphate oxidase is a candidate gene responsible for hypertension in Dahl-S rats. Okuda, T., Sumiya, T., Iwai, N., Miyata, T. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  18. Kinetics and crystal structure of catechol-o-methyltransferase complex with co-substrate and a novel inhibitor with potential therapeutic application. Bonifácio, M.J., Archer, M., Rodrigues, M.L., Matias, P.M., Learmonth, D.A., Carrondo, M.A., Soares-Da-Silva, P. Mol. Pharmacol. (2002) [Pubmed]
  19. Structure-based design, synthesis, and in vitro evaluation of bisubstrate inhibitors for catechol O-methyltransferase (COMT). Masjost, B., Ballmer, P., Borroni, E., Zürcher, G., Winkler, F.K., Jakob-Roetne, R., Diederich, F. Chemistry (Weinheim an der Bergstrasse, Germany) (2000) [Pubmed]
  20. Dopamine formation, from its immediate precursor 3,4-dihydroxyphenylalanine, along the rat digestive tract. Vieira-Coelho, M.A., Soares-da-Silva, P. Fundamental & clinical pharmacology. (1993) [Pubmed]
  21. Production of rat soluble and membrane-bound catechol O-methyltransferase forms from bifunctional mRNAs. Tenhunen, J., Ulmanen, I. Biochem. J. (1993) [Pubmed]
  22. Neuronal expression of catechol O-methyltransferase mRNA in neonatal rat suprachiasmatic nucleus. Shirakawa, T., Abe, M., Oshima, S., Mitome, M., Oguchi, H. Neuroreport (2004) [Pubmed]
  23. Identification of the enzymatic active site of tobacco caffeoyl-coenzyme A O-methyltransferase by site-directed mutagenesis. Hoffmann, L., Maury, S., Bergdoll, M., Thion, L., Erard, M., Legrand, M. J. Biol. Chem. (2001) [Pubmed]
  24. Catechol-O-methyltransferase inhibition increases striatal L-dopa and dopamine: an in vivo study in rats. Brannan, T., Martínez-Tica, J., Yahr, M.D. Neurology (1992) [Pubmed]
  25. Expression and characterization of rat soluble catechol-O-methyltransferase fusion protein. Bonifácio, M.J., Vieira-Coelho, M.A., Soares-da-Silva, P. Protein Expr. Purif. (2001) [Pubmed]
  26. Effect of monoamine oxidase A and B and of catechol-O-methyltransferase inhibition on L-DOPA-induced circling behavior. Heeringa, M.J., d'Agostini, F., DeBoer, P., DaPrada, M., Damsma, G. Journal of neural transmission (Vienna, Austria : 1996) (1997) [Pubmed]
  27. Differential gene expression profiles in colon epithelium of two rat strains with distinct susceptibility to colon carcinogenesis after exposure to PhIP in combination with dietary high fat. Fujiwara, K., Ochiai, M., Ubagai, T., Ohki, M., Ohta, T., Nagao, M., Sugimura, T., Nakagama, H. Cancer Sci. (2003) [Pubmed]
  28. The effect of epinephrine on phenylethanolamine N-methyltransferase in cultured explants of adrenal medulla. Burke, W.J., Davis, J.W., Joh, T.H., Reis, D.J., Horenstein, S., Bhagat, B.D. Endocrinology (1978) [Pubmed]
  29. Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 10. Base- and amino acid modified analogues of S-aristeromycinyl-L-homocysteine. Houston, D.M., Matuszewska, B., Borchardt, R.T. J. Med. Chem. (1985) [Pubmed]
  30. Molecular cloning and characterization of rat liver catechol-O-methyltransferase. Salminen, M., Lundström, K., Tilgmann, C., Savolainen, R., Kalkkinen, N., Ulmanen, I. Gene (1990) [Pubmed]
  31. Quercetin metabolism in the lens: role in inhibition of hydrogen peroxide induced cataract. Cornish, K.M., Williamson, G., Sanderson, J. Free Radic. Biol. Med. (2002) [Pubmed]
  32. Inhibition of catechol-O-methyltransferase by 6,7-dihydroxy-3,4-dihydroisoquinolines related to dopamine: demonstration using liquid chromatography and a novel substrate for O-methylation. Cheng, B.Y., Origitano, T.C., Collins, M.A. J. Neurochem. (1987) [Pubmed]
  33. Effect of orthotopic liver transplantation and chemical denervation of the liver on the activities of hepatic monoamine oxidase and catechol-O-methyltransferase. Wheatley, A.M., McCrodden, J.M., Stuart, E.T., Zhao, D., Shaw, S.G., Tipton, K.F., Blumgart, L.H. Transplantation (1993) [Pubmed]
  34. Soluble and particulate forms of rat catechol-O-methyltransferase distinguished by gel electrophoresis and immune fixation. Grossman, M.H., Creveling, C.R., Rybczynski, R., Braverman, M., Isersky, C., Breakefield, X.O. J. Neurochem. (1985) [Pubmed]
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