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Gene Review:

ALDH2 - aldehyde dehydrogenase 2 family...

Gallus gallus

Li, S.Y. et al., Pappa, A. et al.

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High impact information on ALDH2

Collectively, our data revealed that facilitation of acetaldehyde metabolism by ALDH2 transgene overexpression may prevent acetaldehyde-induced cell injury and activation of stress signals [1].
Efficacy of ALDH2 transfection was verified using green fluorescent protein and ALDH2 enzymatic assay [1].
Transgene-encoding human aldehyde dehydrogenase-2 (ALDH2), which converts acetaldehyde into acetate, was constructed under chicken beta-actin promoter and transfected into human umbilical vein endothelial cells (HUVECs) [1].
It can, therefore, be concluded that corneal expression of ALDH3A1 or ALDH1A1/ALDH2 occurs in a taxon-specific manner, supporting the protective role of these ALDHs in cornea against the UV-induced oxidative damage [2].

Associations of ALDH2 with chemical compounds

These results indicated therapeutic potential of ALDH2 enzyme in the prevention and detoxification of acetaldehyde or alcohol-induced cell injury [1].

References

Overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene prevents acetaldehyde-induced cell injury in human umbilical vein endothelial cells: role of ERK and p38 mitogen-activated protein kinase. Li, S.Y., Gomelsky, M., Duan, J., Zhang, Z., Gomelsky, L., Zhang, X., Epstein, P.N., Ren, J. J. Biol. Chem. (2004) [Pubmed]
Corneal and stomach expression of aldehyde dehydrogenases: from fish to mammals. Pappa, A., Sophos, N.A., Vasiliou, V. Chem. Biol. Interact. (2001) [Pubmed]

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AgaP_AGAP003652	Anopheles gambiae str. PEST
ALDH2B4	Arabidopsis thaliana
AGOS_ACL044W	Ashbya gossypii ATCC 10895
ALDH2	Bos taurus
alh-2	Caenorhabditis elegans
alh-1	Caenorhabditis elegans
ALDH2	Canis lupus familiaris
aldh2.1	Danio rerio
aldh2l	Danio rerio
aldh2.2	Danio rerio
Aldh	Drosophila melanogaster
ALDH2	Homo sapiens
KLLA0C07777g	Kluyveromyces lactis NRRL Y-1140
ALDH2	Macaca mulatta
MGG_03900	Magnaporthe oryzae 70-15
Aldh2	Mus musculus
NCU03415	Neurospora crassa OR74A
ACAD10	Pan troglodytes
Aldh2	Rattus norvegicus
ALD5	Saccharomyces cerevisiae S288c
SPAC9E9.09c	Schizosaccharomyces pombe 972h-
aldh2	Xenopus (Silurana) tropicalis

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