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Gene Review

ALD5  -  aldehyde dehydrogenase (NAD(P)(+)) ALD5

Saccharomyces cerevisiae S288c

Synonyms: ALD3, ALDH5, Aldehyde dehydrogenase 5, mitochondrial, YER073W
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High impact information on ALD5


Biological context of ALD5

  • A 2,661-bp DNA fragment contained an open reading frame encoding mitochondrial ALDH5, with 519 amino acids, of which the N-terminal 23 amino acids were identified as the putative leader sequence [2].
  • ALD3 is induced by a variety of stresses, including osmotic shock, heat shock, glucose exhaustion, oxidative stress and drugs [3].

Associations of ALD5 with chemical compounds

  • The role of mitochondrial ALDH5 in acetaldehyde metabolism has not been defined but appears to be unimportant [2].
  • In contrast, the activity of ALDH5 increased in the presence of K+ ions: 15-fold with NADP and 40-fold with NAD, respectively [2].


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