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Gene Review

MYF6  -  myogenic factor 6 (herculin)

Gallus gallus

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High impact information on MYF6

  • Expression of MyoD, myogenin, MRF4, and Myf-5 converts nonmuscle cells to muscle cells [1].
  • The myogenic basic helix-loop-helix (bHLH) transcription factors, Myf5, MyoD, myogenin and MRF4, are unique in their ability to direct a program of specific gene transcription leading to skeletal muscle phenotype [2].
  • Differential trans-activation of muscle-specific regulatory elements including the mysosin light chain box by chicken MyoD, myogenin, and MRF4 [3].
  • The chicken Myf5 and MRF4 genes are tandemly located on a single genomic DNA fragment, and the chicken Myf5 gene is organized into at least three exons [4].

Analytical, diagnostic and therapeutic context of MYF6

  • The aim of the present study was to develop and standardize a competitive PCR method using standard-curves to quantify transcripts of the myogenic regulatory factors MyoD, Myf-5, Myogenin and MRF4 in chicken embryos [5].
  • The sensitivity of the RT-PCR method permitted the detection of as few as 60 MyoD/Myf-5 molecules per reaction but approximately 600 molecules of MRF4/Myogenin mRNAS were necessary to produce a measurable signal [5].


  1. MyoD and myogenin act on the chicken myosin light-chain 1 gene as distinct transcriptional factors. Asakura, A., Fujisawa-Sehara, A., Komiya, T., Nabeshima, Y., Nabeshima, Y. Mol. Cell. Biol. (1993) [Pubmed]
  2. Delta 1-activated notch inhibits muscle differentiation without affecting Myf5 and Pax3 expression in chick limb myogenesis. Delfini, M.C., Hirsinger, E., Pourquié, O., Duprez, D. Development (2000) [Pubmed]
  3. Differential trans-activation of muscle-specific regulatory elements including the mysosin light chain box by chicken MyoD, myogenin, and MRF4. Fujisawa-Sehara, A., Nabeshima, Y., Komiya, T., Uetsuki, T., Asakura, A., Nabeshima, Y. J. Biol. Chem. (1992) [Pubmed]
  4. Expression of myogenic factors in denervated chicken breast muscle: isolation of the chicken Myf5 gene. Saitoh, O., Fujisawa-Sehara, A., Nabeshima, Y., Periasamy, M. Nucleic Acids Res. (1993) [Pubmed]
  5. Standard-curve competitive RT-PCR quantification of myogenic regulatory factors in chicken embryos. Alvares, L.E., Mantoani, A., Corrente, J.E., Coutinho, L.L. Braz. J. Med. Biol. Res. (2003) [Pubmed]
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