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Gene Review

MRG15  -  CG6363 gene product from transcript CG6363-RA

Drosophila melanogaster

Synonyms: CG6363, DmMRG15, Dmel\CG6363, Dmrg15, Mrg15, ...
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High impact information on MRG15

  • These analyses also suggest that the msl-3/MRG15 duplication occurred after the fungus/animal split, while an independent duplication occurred in plants [1].
  • These data together suggest that the MRG15 chromo domain may function as an adaptor module which can bind to a modified histone H3 in a mode different from that of the HP1/Pc chromo domains [2].
  • The MRG15 chromo domain consists of a beta-barrel and a long alpha-helix and assumes a structure more similar to the Drosophila MOF chromo barrel domain than the typical HP1/Pc chromo domains [2].

Other interactions of MRG15

  • In vitro binding assay results indicate that the MRG15 chromo domain can bind to methylated Lys36, but not methylated Lys4, Lys9 and Lys27 of histone H3 [2].


  1. Origin and evolution of the regulatory gene male-specific lethal-3. Marín, I., Baker, B.S. Mol. Biol. Evol. (2000) [Pubmed]
  2. Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3. Zhang, P., Du, J., Sun, B., Dong, X., Xu, G., Zhou, J., Huang, Q., Liu, Q., Hao, Q., Ding, J. Nucleic Acids Res. (2006) [Pubmed]
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