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Gene Review

msl-3  -  male-specific lethal 3

Drosophila melanogaster

Synonyms: CG8631, DmMsl-3, Dmel\CG8631, MSL, MSL-3, ...
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High impact information on msl-3


Biological context of msl-3


Associations of msl-3 with chemical compounds


Regulatory relationships of msl-3


Other interactions of msl-3

  • We found that MSL-2 binds in a reproducible, partial pattern to the male X chromosome in the absence of MLE or MSL-3, or when ectopically expressed at a low level in females [8].
  • Interaction with MSL1 mediates the activation of MOF in vitro and the targeting of MSL3 to the X-chromosomal territory in vivo [9].
  • By characterizing the MSL3 domain structure and its associated functions, we now found that the nucleic acid binding determinants reside in the N terminus of MSL3, well separable from the C-terminal MRG signatures that form an integrated domain required for MSL1 interaction [9].
  • These analyses also suggest that the msl-3/MRG15 duplication occurred after the fungus/animal split, while an independent duplication occurred in plants [10].


  1. Chromodomains are protein-RNA interaction modules. Akhtar, A., Zink, D., Becker, P.B. Nature (2000) [Pubmed]
  2. MOF-regulated acetylation of MSL-3 in the Drosophila dosage compensation complex. Buscaino, A., Köcher, T., Kind, J.H., Holz, H., Taipale, M., Wagner, K., Wilm, M., Akhtar, A. Mol. Cell (2003) [Pubmed]
  3. Sequence-specific targeting of Drosophila roX genes by the MSL dosage compensation complex. Park, Y., Mengus, G., Bai, X., Kageyama, Y., Meller, V.H., Becker, P.B., Kuroda, M.I. Mol. Cell (2003) [Pubmed]
  4. Molecular characterization of the male-specific lethal-3 gene and investigations of the regulation of dosage compensation in Drosophila. Gorman, M., Franke, A., Baker, B.S. Development (1995) [Pubmed]
  5. Functional integration of the histone acetyltransferase MOF into the dosage compensation complex. Morales, V., Straub, T., Neumann, M.F., Mengus, G., Akhtar, A., Becker, P.B. EMBO J. (2004) [Pubmed]
  6. X-chromosome targeting and dosage compensation are mediated by distinct domains in MSL-3. Buscaino, A., Legube, G., Akhtar, A. EMBO Rep. (2006) [Pubmed]
  7. C2360, a nuclear protein expressed in human proliferative cytotrophoblasts, is a representative member of a novel protein family with a conserved coiled coil-helix-coiled coil-helix domain. Westerman, B.A., Poutsma, A., Steegers, E.A., Oudejans, C.B. Genomics (2004) [Pubmed]
  8. Drosophila male-specific lethal-2 protein: structure/function analysis and dependence on MSL-1 for chromosome association. Lyman, L.M., Copps, K., Rastelli, L., Kelley, R.L., Kuroda, M.I. Genetics (1997) [Pubmed]
  9. The MRG domain mediates the functional integration of MSL3 into the dosage compensation complex. Morales, V., Regnard, C., Izzo, A., Vetter, I., Becker, P.B. Mol. Cell. Biol. (2005) [Pubmed]
  10. Origin and evolution of the regulatory gene male-specific lethal-3. Marín, I., Baker, B.S. Mol. Biol. Evol. (2000) [Pubmed]
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