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GK  -  glycerol kinase

Gallus gallus

 
 
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High impact information on GK

  • In each group the specific activity (mumol/min per g wet wt. of tissue) of hepatic glycerol 3-phosphate dehydrogenase was compared with the activities of the beta-oxoacyl-(acyl-carrier protein) reductase component of fatty acid synthetase, glycerol kinase (EC 2.7.1.30) and lactate dehydrogenase (EC 1.1.1.27) [1].
  • 3. During starvation, the activities of glycerol 3-phosphate dehydrogenase, glycerol kinase and lactate dehydrogenase rose significantly [1].
  • G-kinase modulates osteoclast membrane HCI transport via intermediate protein(s) and may mediate cGMP effects in osteoclasts [2].
  • Osteoclasts express NO-activated guanylate cyclase and cGMP-dependent protein kinase (G-kinase) [2].
 

Analytical, diagnostic and therapeutic context of GK

  • G-kinase reduced membrane HCI transport activity in a concentration-dependent manner, and phosphorylated a 60-kD osteoclast membrane protein, which immunoprecipitation showed is not an H+-ATPase subunit [2].

References

  1. Role of glycerol 3-phosphate dehydrogenase in glyceride metabolism. Effect of diet on enzyme activities in chicken liver. Harding, J.W., Pyeritz, E.A., Copeland, E.S., White, H.B. Biochem. J. (1975) [Pubmed]
  2. Nitric oxide regulation of cGMP production in osteoclasts. Dong, S.S., Williams, J.P., Jordan, S.E., Cornwell, T., Blair, H.C. J. Cell. Biochem. (1999) [Pubmed]
 
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