Chemical Compound Review:
Blenoxane 3-[[2-[2-[2-[[(2S,3R)-2- [[(2S,3S,4R)-4...
Synonyms:
Bleocin, Bleomicin, bleomycin, Bleomicina, Bleomycins, ...
- Bleomycin for hypercalcemia due to cancer. Nijjar, T., Brandes, L.J. N. Engl. J. Med. (1983)
- Bleomycin-resistant DNA synthesis in ataxia telangiectasia cells. Cramer, P., Painter, R.B. Nature (1981)
- Reversibility of severe bleomycin-induced pneumonitis. Brown, W.G., Hasan, F.M., Barbee, R.A. JAMA (1978)
- Young adults with head and neck cancer express increased susceptibility to mutagen-induced chromosome damage. Schantz, S.P., Hsu, T.C., Ainslie, N., Moser, R.P. JAMA (1989)
- Alterations in pulmonary protective enzymes following systemic bleomycin treatment in mice. Filderman, A.E., Genovese, L.A., Lazo, J.S. Biochem. Pharmacol. (1988)
- Conformational flexibility of bleomycin-A2: a carbon-13 spin-lattice relaxation time study. Krishna, N.R., Dallas, J.L., Mooberry, E.S., Sakai, T.T., Allen, R.C., Levy, G.C., Glickson, J.D. Biochem. Biophys. Res. Commun. (1978)
- Responses of Huntington's disease and ataxia telangiectasia lymphoblastoid cells to bleomycin. Imray, F.P., Kidson, C. Chem. Biol. Interact. (1983)
- Toxic effects of bleomycin on the hypothalamus following its administration into a cystic craniopharyngioma. Haisa, T., Ueki, K., Yoshida, S. British journal of neurosurgery. (1994)
- Therapy of advanced esophageal cancer with bleomycin, irradiation and combination of bleomycin with irradiation. Kolarić, K., Maricić, Z., Dujmović, I., Roth, A. Tumori. (1976)
- A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis. Nagase, T., Uozumi, N., Ishii, S., Kita, Y., Yamamoto, H., Ohga, E., Ouchi, Y., Shimizu, T. Nat. Med. (2002)
- Bleomycin causes release of nucleosomes from chromatin and chromosomes. Kuo, M.T., Hsu, T.C. Nature (1978)
- Crystal structure of a conserved protease that binds DNA: the bleomycin hydrolase, Gal6. Joshua-Tor, L., Xu, H.E., Johnston, S.A., Rees, D.C. Science (1995)
- Potentiation of bleomycin lethality by anticalmodulin drugs: a role for calmodulin in DNA repair. Chafouleas, J.G., Bolton, W.E., Means, A.R. Science (1984)
- Fatal pulmonary reaction from low doses of bleomycin. An idiosyncratic tissue response. Iacovino, J.R., Leitner, J., Abbas, A.K., Lokich, J.J., Snider, G.L. JAMA (1976)
- Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. Wang, X.M., Zhang, Y., Kim, H.P., Zhou, Z., Feghali-Bostwick, C.A., Liu, F., Ifedigbo, E., Xu, X., Oury, T.D., Kaminski, N., Choi, A.M. J. Exp. Med. (2006)
- Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. Piguet, P.F., Collart, M.A., Grau, G.E., Kapanci, Y., Vassalli, P. J. Exp. Med. (1989)
- Antitumor and toxic effects of combination chemotherapy with bleomycin and a phenothiazine anticalmodulin agent. Hait, W.N., Lazo, J.S., Chen, D.L., Gallichio, V.S., Filderman, A.E. J. Natl. Cancer Inst. (1988)
- TGF-beta is a critical mediator of acute lung injury. Pittet, J.F., Griffiths, M.J., Geiser, T., Kaminski, N., Dalton, S.L., Huang, X., Brown, L.A., Gotwals, P.J., Koteliansky, V.E., Matthay, M.A., Sheppard, D. J. Clin. Invest. (2001)
- Nitric oxide-dependent activation of p53 suppresses bleomycin-induced apoptosis in the lung. Davis, D.W., Weidner, D.A., Holian, A., McConkey, D.J. J. Exp. Med. (2000)
- Inherited susceptibility to bleomycin-induced chromatid breaks in cultured peripheral blood lymphocytes. Cloos, J., Nieuwenhuis, E.J., Boomsma, D.I., Kuik, D.J., van der Sterre, M.L., Arwert, F., Snow, G.B., Braakhuis, B.J. J. Natl. Cancer Inst. (1999)
- Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse. Olman, M.A., Mackman, N., Gladson, C.L., Moser, K.M., Loskutoff, D.J. J. Clin. Invest. (1995)
- Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation. Khalil, N., Bereznay, O., Sporn, M., Greenberg, A.H. J. Exp. Med. (1989)
- Prevention of bleomycin-induced pulmonary fibrosis after adenovirus-mediated transfer of the bacterial bleomycin resistance gene. Tran, P.L., Weinbach, J., Opolon, P., Linares-Cruz, G., Reynes, J.P., Grégoire, A., Kremer, E., Durand, H., Perricaudet, M. J. Clin. Invest. (1997)
- Nitric oxide upregulates expression of DNA-PKcs to protect cells from DNA-damaging anti-tumour agents. Xu, W., Liu, L., Smith, G.C., Charles, G. Nat. Cell Biol. (2000)
- Hypersensitivity of cultured ataxia-telangiectasia cells to etoposide. Henner, W.D., Blazka, M.E. J. Natl. Cancer Inst. (1986)
- Effect of heating on lethality due to hyperthermia and selected chemotherapeutic drugs. Herman, T.S., Sweets, C.C., White, D.M., Gerner, E.W. J. Natl. Cancer Inst. (1982)
- Effects of nicotinamide, isonicotinamide, and bleomycin on DNA synthesis and repair in rat hepatocytes and hepatoma cells. Barra, R., Randolph, V., Sumas, M., Lanighan, K., Lea, M.A. J. Natl. Cancer Inst. (1982)
- Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. Nakao, A., Fujii, M., Matsumura, R., Kumano, K., Saito, Y., Miyazono, K., Iwamoto, I. J. Clin. Invest. (1999)
- Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. Phillips, R.J., Burdick, M.D., Hong, K., Lutz, M.A., Murray, L.A., Xue, Y.Y., Belperio, J.A., Keane, M.P., Strieter, R.M. J. Clin. Invest. (2004)
- Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest. Franchitto, A., Pichierri, P. J. Cell Biol. (2002)
- Overexpression of a Rrp1 transgene reduces the somatic mutation and recombination frequency induced by oxidative DNA damage in Drosophila melanogaster. Szakmary, A., Huang, S.M., Chang, D.T., Beachy, P.A., Sander, M. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Craniopharyngiomas. Karavitaki, N., Cudlip, S., Adams, C.B., Wass, J.A. Endocr. Rev. (2006)
- Large-dose bleomycin therapy and pulmonary toxicity. A possible role of prior radiotherapy. Samuels, M.L., Johnson, D.E., Holoye, P.Y., Lanzotti, V.J. JAMA (1976)
- Routine pulmonary function tests during bleomycin therapy. Tests may be ineffective and potentially misleading. Lewis, B.M., Izbicki, R. JAMA (1980)