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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

FOSL2  -  FOS-like antigen 2

Gallus gallus

Synonyms: PLB1, fra-2
 
 
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High impact information on FOSL2

  • Site B binds CREB and/or CREM to enhance expression in the lens and binds an AP-1 complex including CREB, Fra2 and/or JunD which interacts with USF on site A to repress expression in fibroblasts [1].
  • Of the other calcium-binding proteins examined, namely, troponin-C, S-100 protein, phospholipase A, phospholipase B and myosin light chain, only troponin-C displayed any significant calcium-specific binding of trifluoperazine [2].

References

  1. A complex array of positive and negative elements regulates the chicken alpha A-crystallin gene: involvement of Pax-6, USF, CREB and/or CREM, and AP-1 proteins. Cvekl, A., Sax, C.M., Bresnick, E.H., Piatigorsky, J. Mol. Cell. Biol. (1994) [Pubmed]
  2. Specificity of the binding of trifluoperazine to the calcium-dependent activator of phosphodiesterase and to a series of other calcium-binding proteins. Levin, R.M., Weiss, B. Biochim. Biophys. Acta (1978) [Pubmed]
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