Gene Review:
klg - klingon
Drosophila melanogaster
Synonyms:
CG6669, CT20712, Dmel\CG6669, Klg, h214, ...
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High impact information on klg
- klingon, a novel member of the Drosophila immunoglobulin superfamily, is required for the development of the R7 photoreceptor neuron [1].
- Genetic analysis has revealed that klingon is an essential gene that participates in the development of the R7 neuron [1].
- Ectopic expression of klingon in all neurons in a sevenless background can alter the position of the R8 rhabdomere [1].
- Starting from the H214 enhancer trap line, we identified a transcription unit, klingon, that encodes a putative protein of 528 amino acids and contains three C2-type Immunoglobulin-like domains followed by one fibronectin type III repeat [1].
- When Klingon is expressed in S2 tissue culture cells, it is associated with the cell membrane by a glycosyl-phosphatidylinositol linkage and can mediate homophilic adhesion [1].
References
- klingon, a novel member of the Drosophila immunoglobulin superfamily, is required for the development of the R7 photoreceptor neuron. Butler, S.J., Ray, S., Hiromi, Y. Development (1997) [Pubmed]
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