Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

fzo - fuzzy onions

Drosophila melanogaster

Synonyms: CG4568, Dmel\CG4568, Protein fuzzy onions, Transmembrane GTPase fzo, anon-WO0125274.1, ...

Hwa, J.J. et al., Hermann, G.J. et al.

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High impact information on fzo

In Drosophila, mutations in the fuzzy onions (fzo) GTPase block a developmentally regulated mitochondrial fusion event during spermatogenesis [1].
Differential expression of the Drosophila mitofusin genes fuzzy onions (fzo) and dmfn [2].
In contrast, expression of the fzo was tightly restricted to the male germ line, with mRNA accumulation in spermatocytes and early spermatids [2].

Anatomical context of fzo

In addition, expression of dmfn and fzo in the same cell type, primary spermatocytes, was under control of different regulatory mechanisms [2].

References

Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. Hermann, G.J., Thatcher, J.W., Mills, J.P., Hales, K.G., Fuller, M.T., Nunnari, J., Shaw, J.M. J. Cell Biol. (1998) [Pubmed]
Differential expression of the Drosophila mitofusin genes fuzzy onions (fzo) and dmfn. Hwa, J.J., Hiller, M.A., Fuller, M.T., Santel, A. Mech. Dev. (2002) [Pubmed]

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