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Gene Review

Irk2  -  Inwardly rectifying potassium channel 2

Drosophila melanogaster

Synonyms: CG10180, CG4370, Dmel\CG4370, dKir, dKirII, ...
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High impact information on Irk2

  • Whole mount in situ hybridizations revealed dKirI transcripts absent from embryos, but dKirII and dKirIII are expressed in the embryonic hind gut and in Malpighian tubules, respectively, thus covering the entire osmoregulatory system of the developing fly [1].
  • In contrast, heterologous expression of wild type dKirI and dKirII in Drosophila S2 cells readily evoked typical inwardly rectifying K(+) currents, which were weakly sensitive to Ba(2+) [1].

Analytical, diagnostic and therapeutic context of Irk2

  • A recent microarray analysis of Drosophila tubule identified three extremely abundant and enriched K(+) channel genes encoding the three inward rectifier channels of Drosophila: ir, irk2 and irk3 [2].


  1. Inwardly rectifying K+ (Kir) channels in Drosophila. A crucial role of cellular milieu factors Kir channel function. Döring, F., Wischmeyer, E., Kühnlein, R.P., Jäckle, H., Karschin, A. J. Biol. Chem. (2002) [Pubmed]
  2. Sulphonylurea sensitivity and enriched expression implicate inward rectifier K+ channels in Drosophila melanogaster renal function. Evans, J.M., Allan, A.K., Davies, S.A., Dow, J.A. J. Exp. Biol. (2005) [Pubmed]
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