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Gene Review

Irk1  -  Inwardly rectifying potassium channel 1

Drosophila melanogaster

Synonyms: CG13836, CG44159, CG6747, DIR, Dir, ...
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Disease relevance of Ir


High impact information on Ir


Chemical compound and disease context of Ir

  • Here we compare the action of the five effector genes shibire(ts1), Tetanus toxin light chain (TNT), reaper, Diphtheria toxin A-chain (DTA), and inwardly rectifying potassium channel (Kir2.1) and show differences in their efficiency depending on the target cells and the timing of induction [5].


  1. Condensation of the central nervous system in embryonic Drosophila is inhibited by blocking hemocyte migration or neural activity. Olofsson, B., Page, D.T. Dev. Biol. (2005) [Pubmed]
  2. Inwardly rectifying K+ (Kir) channels in Drosophila. A crucial role of cellular milieu factors Kir channel function. Döring, F., Wischmeyer, E., Kühnlein, R.P., Jäckle, H., Karschin, A. J. Biol. Chem. (2002) [Pubmed]
  3. Characterization of Dir: a putative potassium inward rectifying channel in Drosophila. MacLean, S.J., Andrews, B.C., Verheyen, E.M. Mech. Dev. (2002) [Pubmed]
  4. DmGluRA, a Drosophila metabotropic glutamate receptor, activates G-protein inwardly rectifying potassium channels in Xenopus oocytes. Raymond, V., Hamon, A., Grau, Y., Lapied, B. Neurosci. Lett. (1999) [Pubmed]
  5. Differential potencies of effector genes in adult Drosophila. Thum, A.S., Knapek, S., Rister, J., Dierichs-Schmitt, E., Heisenberg, M., Tanimoto, H. J. Comp. Neurol. (2006) [Pubmed]
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