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Gene Review:

Irk1 - Inwardly rectifying potassium channel 1

Drosophila melanogaster

Synonyms: CG13836, CG44159, CG6747, DIR, Dir, ...

Thum, A.S. et al., Raymond, V. et al., Döring, F. et al., Olofsson, B. et al., MacLean, S.J. et al.

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Disease relevance of Ir

Blocking neural activity by targeted expression of tetanus toxin light chain or an inwardly rectifying potassium channel also inhibits condensation [1].

High impact information on Ir

In contrast, heterologous expression of wild type dKirI and dKirII in Drosophila S2 cells readily evoked typical inwardly rectifying K(+) currents, which were weakly sensitive to Ba(2+) [2].
In fact, there are only three genes (including Dir) encoding putative inward rectifiers in the Drosophila genome [3].
Xenopus oocytes were coinjected with cDNAs encoding the Drosophila melanogaster metabotropic glutamate receptor (DmGluRA) and two mammalian G-protein inwardly rectifying potassium channel subunits (GIRK1 and GIRK2) [4].

Chemical compound and disease context of Ir

Here we compare the action of the five effector genes shibire(ts1), Tetanus toxin light chain (TNT), reaper, Diphtheria toxin A-chain (DTA), and inwardly rectifying potassium channel (Kir2.1) and show differences in their efficiency depending on the target cells and the timing of induction [5].

References

Condensation of the central nervous system in embryonic Drosophila is inhibited by blocking hemocyte migration or neural activity. Olofsson, B., Page, D.T. Dev. Biol. (2005) [Pubmed]
Inwardly rectifying K+ (Kir) channels in Drosophila. A crucial role of cellular milieu factors Kir channel function. Döring, F., Wischmeyer, E., Kühnlein, R.P., Jäckle, H., Karschin, A. J. Biol. Chem. (2002) [Pubmed]
Characterization of Dir: a putative potassium inward rectifying channel in Drosophila. MacLean, S.J., Andrews, B.C., Verheyen, E.M. Mech. Dev. (2002) [Pubmed]
DmGluRA, a Drosophila metabotropic glutamate receptor, activates G-protein inwardly rectifying potassium channels in Xenopus oocytes. Raymond, V., Hamon, A., Grau, Y., Lapied, B. Neurosci. Lett. (1999) [Pubmed]
Differential potencies of effector genes in adult Drosophila. Thum, A.S., Knapek, S., Rister, J., Dierichs-Schmitt, E., Heisenberg, M., Tanimoto, H. J. Comp. Neurol. (2006) [Pubmed]

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AgaP_AGAP001280	Anopheles gambiae str. PEST
KCNJ2	Bos taurus
irk-1	Caenorhabditis elegans
KCNJ2	Canis lupus familiaris
kcnj2a	Danio rerio
KCNJ2	Gallus gallus
KCNJ2	Homo sapiens
KCNJ2	Macaca mulatta
Kcnj2	Mus musculus
KCNJ2	Pan troglodytes
Kcnj2	Rattus norvegicus
kcnj2	Xenopus (Silurana) tropicalis

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