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Gene Review

Kcnj12  -  potassium inwardly-rectifying channel,...

Mus musculus

Synonyms: ATP-sensitive inward rectifier potassium channel 12, IRK-2, IRK2, Inward rectifier K(+) channel Kir2.2, Irk2, ...
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High impact information on Kcnj12

  • Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation [1].
  • An increase in the extracellular K(+) concentration from 6 to 15 mmol/L caused Ba(2+)-sensitive dilations in pressurized cerebral arteries from control and Kir2.2 mice [1].
  • Expression of Kir2.2 in polarized epithelial cells resulted in targeting of the channels to the basolateral membrane and co-localization with SAP97 and CASK, whereas a dominant interfering form of CASK caused the channels to mislocalize [2].
  • In the brain, the abundance of mRNA for MB-IRK2 was much higher in cerebellum than in forebrain and vice versa in the case of MB-IRK1 [3].
  • We have cloned a second class of inward rectifier potassium channels, designated MB-IRK2, from a mouse brain cDNA library [3].

Biological context of Kcnj12

  • Owing to their localization on RNO10 and their involvement in a similar pathology in human and mouse, Myo15 and Kcnj12 can be regarded as candidate genes for the deafblind phenotype of the LEW-ci2 rat [4].
  • Assignment of the murine inward rectifier potassium channel Irk2 (Kir2.2) gene to the central region of mouse chromosome 11 [5].
  • Kir2.2-/- exhibited a smaller increase in tidal volume and minute ventilation volume than the FVB mouse in response to hypercapnic challenge on days 14-15 [6].
  • We designated them mouse brain (MB)- IRK1, MB-IRK2, and MB-IRK3, based on their amino acid sequences and the electrophysiological properties of currents expressed in Xenopus oocytes [7].

Anatomical context of Kcnj12


Associations of Kcnj12 with chemical compounds

  • Both the Kir2.1 and Kir2.2 currents recorded from inside-out patches exhibited outward transients similar to those of ventricular I(K1) in the presence of 5-10 microM spermine and 0.6-1.1 mM Mg(2+), and their amplitudes were diminished by increasing the spermine or spermidine concentrations [9].

Other interactions of Kcnj12

  • The single channel recordings revealed, however, that the unitary conductance of MB-IRKI was approximately 22pS; MB-IRK2, approximately 34pS; and MB-IRK3, approximately 12pS [7].

Analytical, diagnostic and therapeutic context of Kcnj12

  • We also examined developmental changes in m-RNA expression of Kir2.2 in the brainstem of the FVB mouse using quantitative real-time PCR assay [6].


  1. Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation. Zaritsky, J.J., Eckman, D.M., Wellman, G.C., Nelson, M.T., Schwarz, T.L. Circ. Res. (2000) [Pubmed]
  2. A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. Leonoudakis, D., Conti, L.R., Radeke, C.M., McGuire, L.M., Vandenberg, C.A. J. Biol. Chem. (2004) [Pubmed]
  3. Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain. Takahashi, N., Morishige, K., Jahangir, A., Yamada, M., Findlay, I., Koyama, H., Kurachi, Y. J. Biol. Chem. (1994) [Pubmed]
  4. The circling behavior of the deafblind LEW-ci2 rat is linked to a segment of RNO10 containing Myo15 and Kcnj12. Chwalisz, W.T., Koelsch, B.U., Kindler-Röhrborn, A., Hedrich, H.J., Wedekind, D. Mamm. Genome (2003) [Pubmed]
  5. Assignment of the murine inward rectifier potassium channel Irk2 (Kir2.2) gene to the central region of mouse chromosome 11. Takumi, T., Tsuji, L., Kondo, C., Takahashi, N., Morishige, K., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Kurachi, Y. Genomics (1996) [Pubmed]
  6. Role of Kir2.2 in hypercapnic ventilatory response during postnatal development of mouse. Oyamada, Y., Yamaguchi, K., Murai, M., Hakuno, H., Ishizaka, A. Respiratory physiology & neurobiology. (2005) [Pubmed]
  7. Molecular and functional heterogeneity of inward rectifier potassium channels in brain and heart. Kurachi, Y., Takahashi, N. J. Card. Fail. (1996) [Pubmed]
  8. Differential distribution of classical inwardly rectifying potassium channel mRNAs in the brain: comparison of IRK2 with IRK1 and IRK3. Horio, Y., Morishige, K., Takahashi, N., Kurachi, Y. FEBS Lett. (1996) [Pubmed]
  9. Different intracellular polyamine concentrations underlie the difference in the inward rectifier K(+) currents in atria and ventricles of the guinea-pig heart. Yan, D.H., Nishimura, K., Yoshida, K., Nakahira, K., Ehara, T., Igarashi, K., Ishihara, K. J. Physiol. (Lond.) (2005) [Pubmed]
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