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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TfIIA-S  -  Transcription-factor-IIA-S

Drosophila melanogaster

Synonyms: BcDNA:RE44302, CG5163, Dmel\CG5163, F121, General transcription factor IIA subunit 2, ...
 
 
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High impact information on TfIIA-S

  • Drosophila TFIIA-S is up-regulated and required during Ras-mediated photoreceptor determination [1].
  • Subunit interaction studies indicate that dTFIIA-S binds to an amino-terminal domain of dTFIIA-L, which likely corresponds to the endogenous 30-kD processed species [2].
  • Drosophila TFIIA directs cooperative DNA binding with TBP and mediates transcriptional activation [2].
  • Importantly, this phenotype is suppressed by overexpression of the TFIIA subunits, indicating that the yTAF145 inhibitory domain is involved in TFIIA function [3].
 

Other interactions of TfIIA-S

  • We reported previously the characterization of cDNAs that encode a precursor (dTFIIA-L) of the Drosophila TFIIA 30- and 20-kD subunits [2].
 

Analytical, diagnostic and therapeutic context of TfIIA-S

References

  1. Drosophila TFIIA-S is up-regulated and required during Ras-mediated photoreceptor determination. Zeidler, M.P., Yokomori, K., Tjian, R., Mlodzik, M. Genes Dev. (1996) [Pubmed]
  2. Drosophila TFIIA directs cooperative DNA binding with TBP and mediates transcriptional activation. Yokomori, K., Zeidler, M.P., Chen, J.L., Verrijzer, C.P., Mlodzik, M., Tjian, R. Genes Dev. (1994) [Pubmed]
  3. The yeast TAF145 inhibitory domain and TFIIA competitively bind to TATA-binding protein. Kokubo, T., Swanson, M.J., Nishikawa, J.I., Hinnebusch, A.G., Nakatani, Y. Mol. Cell. Biol. (1998) [Pubmed]
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