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Gene Review

TfIIA-L  -  Transcription factor IIA L

Drosophila melanogaster

Synonyms: CG5930, CT18631, Dmel\CG5930, General transcription factor IIA subunit 1, TFIIA, ...
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High impact information on TfIIA-L


Other interactions of TfIIA-L

  • Coimmunoprecipitation studies with anti-dTBP, anti-dTFIIA-L, and anti-TAF antibodies indicated a tight association of the endogenous dTFIIA and dTFIID [4].
  • Activator-dependent reinitiation of transcription, obviating the slow assembly of the TFIID-TFIIA complex on a promoter, may be especially crucial for genes requiring a fast response to inducers [5].
  • We reported previously the characterization of cDNAs that encode a precursor (dTFIIA-L) of the Drosophila TFIIA 30- and 20-kD subunits [3].

Analytical, diagnostic and therapeutic context of TfIIA-L


  1. TAFs and TFIIA mediate differential utilization of the tandem Adh promoters. Hansen, S.K., Tjian, R. Cell (1995) [Pubmed]
  2. The mammalian transcriptional repressor RBP (CBF1) targets TFIID and TFIIA to prevent activated transcription. Olave, I., Reinberg, D., Vales, L.D. Genes Dev. (1998) [Pubmed]
  3. Drosophila TFIIA directs cooperative DNA binding with TBP and mediates transcriptional activation. Yokomori, K., Zeidler, M.P., Chen, J.L., Verrijzer, C.P., Mlodzik, M., Tjian, R. Genes Dev. (1994) [Pubmed]
  4. Drosophila TFIIA-L is processed into two subunits that are associated with the TBP/TAF complex. Yokomori, K., Admon, A., Goodrich, J.A., Chen, J.L., Tjian, R. Genes Dev. (1993) [Pubmed]
  5. Heat shock factor increases the reinitiation rate from potentiated chromatin templates. Sandaltzopoulos, R., Becker, P.B. Mol. Cell. Biol. (1998) [Pubmed]
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