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Gene Review

pkd2  -  polycystic kidney disease 2

Danio rerio

Synonyms: SO:0000704
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High impact information on pkd2

  • For further exploration of the in vivo functions of Polycystin-2, this study examined its expression and function during zebrafish embryogenesis. pkd2 mRNA is ubiquitously expressed, and its presence in the larval kidney could be confirmed by reverse transcription-PCR on isolated pronephroi [1].
  • We have cloned zebrafish homologues of polaris and pkd2 [2].
  • By targeting morpholinos to DFCs/KV, we show that polaris and pkd2 are required in DFCs/KV for normal LR development [2].


  1. Polycystin-2 immunolocalization and function in zebrafish. Obara, T., Mangos, S., Liu, Y., Zhao, J., Wiessner, S., Kramer-Zucker, A.G., Olale, F., Schier, A.F., Drummond, I.A. J. Am. Soc. Nephrol. (2006) [Pubmed]
  2. Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis. Bisgrove, B.W., Snarr, B.S., Emrazian, A., Yost, H.J. Dev. Biol. (2005) [Pubmed]
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