Gene Review:
Pkd2 - polycystic kidney disease 2
Mus musculus
Synonyms:
C030034P18Rik, PC2, Polycystic kidney disease 2 protein homolog, Polycystin-2, TRPP2, ...
- A transcriptional network in polycystic kidney disease. Gresh, L., Fischer, E., Reimann, A., Tanguy, M., Garbay, S., Shao, X., Hiesberger, T., Fiette, L., Igarashi, P., Yaniv, M., Pontoglio, M. EMBO J. (2004)
- Somatic inactivation of Pkd2 results in polycystic kidney disease. Wu, G., D'Agati, V., Cai, Y., Markowitz, G., Park, J.H., Reynolds, D.M., Maeda, Y., Le, T.C., Hou, H., Kucherlapati, R., Edelmann, W., Somlo, S. Cell (1998)
- Calcium dependence of polycystin-2 channel activity is modulated by phosphorylation at Ser812. Cai, Y., Anyatonwu, G., Okuhara, D., Lee, K.B., Yu, Z., Onoe, T., Mei, C.L., Qian, Q., Geng, L., Wiztgall, R., Ehrlich, B.E., Somlo, S. J. Biol. Chem. (2004)
- Haploinsufficiency of Pkd2 is associated with increased tubular cell proliferation and interstitial fibrosis in two murine Pkd2 models. Chang, M.Y., Parker, E., Ibrahim, S., Shortland, J.R., Nahas, M.E., Haylor, J.L., Ong, A.C. Nephrol. Dial. Transplant. (2006)
- Altered expression pattern of polycystin-2 in acute and chronic renal tubular diseases. Obermüller, N., Cai, Y., Kränzlin, B., Thomson, R.B., Gretz, N., Kriz, W., Somlo, S., Witzgall, R. J. Am. Soc. Nephrol. (2002)
- Polycystin-2 expression is regulated by a PC2-binding domain in the intracellular portion of fibrocystin. Kim, I., Li, C., Liang, D., Chen, X.Z., Coffy, R.J., Ma, J., Zhao, P., Wu, G. J. Biol. Chem. (2008)
- Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nauli, S.M., Alenghat, F.J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A.E., Lu, W., Brown, E.M., Quinn, S.J., Ingber, D.E., Zhou, J. Nat. Genet. (2003)
- Cardiac defects and renal failure in mice with targeted mutations in Pkd2. Wu, G., Markowitz, G.S., Li, L., D'Agati, V.D., Factor, S.M., Geng, L., Tibara, S., Tuchman, J., Cai, Y., Park, J.H., van Adelsberg, J., Hou, H., Kucherlapati, R., Edelmann, W., Somlo, S. Nat. Genet. (2000)
- Polycystin-L is a calcium-regulated cation channel permeable to calcium ions. Chen, X.Z., Vassilev, P.M., Basora, N., Peng, J.B., Nomura, H., Segal, Y., Brown, E.M., Reeders, S.T., Hediger, M.A., Zhou, J. Nature (1999)
- CD2-associated protein directly interacts with the actin cytoskeleton. Lehtonen, S., Zhao, F., Lehtonen, E. Am. J. Physiol. Renal Physiol. (2002)
- Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. Li, X., Luo, Y., Starremans, P.G., McNamara, C.A., Pei, Y., Zhou, J. Nat. Cell Biol. (2005)
- Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells. Qian, Q., Hunter, L.W., Li, M., Marin-Padilla, M., Prakash, Y.S., Somlo, S., Harris, P.C., Torres, V.E., Sieck, G.C. Hum. Mol. Genet. (2003)
- Cloning and characterization of the murine pkd2 promoter. Park, J.H., Li, L., Cai, Y., Hayashi, T., Dong, F., Maeda, Y., Rubin, C., Somlo, S., Wu, G. Genomics (2000)
- Molecular cloning, cDNA sequence analysis, and chromosomal localization of mouse Pkd2. Wu, G., Mochizuki, T., Le, T.C., Cai, Y., Hayashi, T., Reynolds, D.M., Somlo, S. Genomics (1997)
- The ion channel polycystin-2 is required for left-right axis determination in mice. Pennekamp, P., Karcher, C., Fischer, A., Schweickert, A., Skryabin, B., Horst, J., Blum, M., Dworniczak, B. Curr. Biol. (2002)
- Distinct and common developmental expression patterns of the murine Pkd2 and Pkd1 genes. Guillaume, R., Trudel, M. Mech. Dev. (2000)
- Loss of primary cilia results in deregulated and unabated apical calcium entry in ARPKD collecting duct cells. Siroky, B.J., Ferguson, W.B., Fuson, A.L., Xie, Y., Fintha, A., Komlosi, P., Yoder, B.K., Schwiebert, E.M., Guay-Woodford, L.M., Bell, P.D. Am. J. Physiol. Renal Physiol. (2006)
- Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis. Bisgrove, B.W., Snarr, B.S., Emrazian, A., Yost, H.J. Dev. Biol. (2005)
- Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia. Luo, Y., Vassilev, P.M., Li, X., Kawanabe, Y., Zhou, J. Mol. Cell. Biol. (2003)
- Pkd2+/- vascular smooth muscles develop exaggerated vasocontraction in response to phenylephrine stimulation. Qian, Q., Hunter, L.W., Du, H., Ren, Q., Han, Y., Sieck, G.C. J. Am. Soc. Nephrol. (2007)
- Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells. Grimm, D.H., Cai, Y., Chauvet, V., Rajendran, V., Zeltner, R., Geng, L., Avner, E.D., Sweeney, W., Somlo, S., Caplan, M.J. J. Biol. Chem. (2003)
- Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene. Boulter, C., Mulroy, S., Webb, S., Fleming, S., Brindle, K., Sandford, R. Proc. Natl. Acad. Sci. U.S.A. (2001)
- More than colocalizing with polycystin-1, polycystin-L is in the centrosome. Bui-Xuan, E.F., Li, Q., Chen, X.Z., Boucher, C.A., Sandford, R., Zhou, J., Basora, N. Am. J. Physiol. Renal Physiol. (2006)
- In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2. Lehtonen, S., Ora, A., Olkkonen, V.M., Geng, L., Zerial, M., Somlo, S., Lehtonen, E. J. Biol. Chem. (2000)
- Analysis of the polycystins in aortic vascular smooth muscle cells. Qian, Q., Li, M., Cai, Y., Ward, C.J., Somlo, S., Harris, P.C., Torres, V.E. J. Am. Soc. Nephrol. (2003)
- A splice form of polycystin-2, lacking exon 7, does not interact with polycystin-1. Hackmann, K., Markoff, A., Qian, F., Bogdanova, N., Germino, G.G., Pennekamp, P., Dworniczak, B., Horst, J., Gerke, V. Hum. Mol. Genet. (2005)