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Gene Review:

Moca-cyp - CG1866 gene product from transcript CG1866-RC

Drosophila melanogaster

Synonyms: BEST:LD38313, CG1866, Dmel\CG1866, anon-WO0147981.13, anon-WO0147981.4, ...

Cavarec, L. et al.

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High impact information on Moca-cyp

Identification and characterization of Moca-cyp. A Drosophila melanogaster nuclear cyclophilin [1].
By embryo in situ RNA hybridization and immunostaining, we show that the expression of Moca-cyp is regulated during embryogenesis of Drosophila [1].
Compared with cyclophilin 18, the enzymatic activity carried by the PPIase domain of Moca-cyp is low, exhibits characteristic substrate specificity, and shows a reduced sensitivity to the drug cyclosporin A (CsA) [1].
The single-copy Moca-cyp gene, which is localized on chromosome 3R, was cloned and sequenced [1].

Analytical, diagnostic and therapeutic context of Moca-cyp

The sequence alignment of the gene against Moca-cyp cDNA allowed us to define its intron/exon structure and to identify a variant cDNA corresponding to an alternatively spliced mRNA [1].

References

Identification and characterization of Moca-cyp. A Drosophila melanogaster nuclear cyclophilin. Cavarec, L., Kamphausen, T., Dubourg, B., Callebaut, I., Lemeunier, F., Métivier, D., Feunteun, J., Fischer, G., Modjtahedi, N. J. Biol. Chem. (2002) [Pubmed]

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