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Gene Review:

Gycalpha99B - Guanylyl cyclase alpha-subunit at 99B

Drosophila melanogaster

Synonyms: CG1912, Dgc1, Dgcalpha1, Dmel\CG1912, GCalpha1, ...

Shah, S. et al., Elphick, M.R. et al., Riedl, C.A. et al., Yoshikawa, S. et al.

Elphick, Jones,

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High impact information on Gycalpha99B

Our results indicate that Dgc alpha 1 and Dgc beta 1 are soluble guanylyl cyclase alpha and beta subunits that are capable of forming a functional guanylyl cyclase heterodimer [1].
We identified two Drosophila genes (dgc alpha 1 and dgc beta 1) that encode the soluble guanylyl cyclase alpha and beta subunits, respectively [1].
The enriched distribution in the eye suggests that dgc1 may have a role in phototransduction [2].

Analytical, diagnostic and therapeutic context of Gycalpha99B

Analysis of locust brain and locust eye homogenates in Western blots using X-peptide antisera revealed specific staining of a approximately 65 kDa band, which is similar to the expected molecular mass for a SGCalpha-subunit [3].
We performed DNA microarray analyses to compare transcriptional changes induced by a dgcalpha1 mutation in both rover and sitter wildtype genetic backgrounds [4].

References

Two Drosophila genes that encode the alph and beta subunits of the brain soluble guanylyl cyclase. Shah, S., Hyde, D.R. J. Biol. Chem. (1995) [Pubmed]
Isolation of a Drosophila gene encoding a head-specific guanylyl cyclase. Yoshikawa, S., Miyamoto, I., Aruga, J., Furuichi, T., Okano, H., Mikoshiba, K. J. Neurochem. (1993) [Pubmed]
Localization of soluble guanylyl cyclase alpha-subunit in identified insect neurons. Elphick, M.R., Jones, I.W. Brain Res. (1998) [Pubmed]
Drosophila soluble guanylyl cyclase mutants exhibit increased foraging locomotion: behavioral and genomic investigations. Riedl, C.A., Neal, S.J., Robichon, A., Westwood, J.T., Sokolowski, M.B. Behav. Genet. (2005) [Pubmed]

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