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Gene Review:

Kul - Kuzbanian-like

Drosophila melanogaster

Synonyms: ADAM10, CG1964, CT3146, Dmel\CG1964

Sapir, A. et al., Jarriault, S. et al., Yan, Y. et al.

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High impact information on Kul

The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors [1].
In the absence of Kul in the developing wing, the level of Dl in cells that normally receive the signal is elevated, and subsequent alterations in the directionality of Notch signaling lead to prominent phenotypic defects [2].
In Caenorhabditis elegans, genetic evidence has implicated SUP-17, the ortholog of Drosophila Kuzbanian and mammalian ADAM10, as the protease that mediates this event [3].

References

The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors. Yan, Y., Shirakabe, K., Werb, Z. J. Cell Biol. (2002) [Pubmed]
Unidirectional Notch signaling depends on continuous cleavage of Delta. Sapir, A., Assa-Kunik, E., Tsruya, R., Schejter, E., Shilo, B.Z. Development (2005) [Pubmed]
Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE. Jarriault, S., Greenwald, I. Dev. Biol. (2005) [Pubmed]

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