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Gene Review

kuz  -  kuzbanian

Drosophila melanogaster

Synonyms: 11410, 34Da, ADAM10, BG:DS07660.3, CG7147, ...
 
 
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High impact information on kuz

  • The kuzbanian (kuz) gene described here is essential for the partitioning of neural and nonneuronal cells during development of both the central and peripheral nervous systems in Drosophila [1].
  • kuzbanian-mediated cleavage of Drosophila Notch [2].
  • Loss of Kuzbanian, a member of the ADAM family of metalloproteases, produces neurogenic phenotypes in Drosophila [2].
  • The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors [3].
  • Recent studies suggest that Delta is cleaved to release an extracellular fragment, DlEC, by a mechanism that involves the activity of the metalloprotease Kuzbanian; however, the functional significance of that cleavage remains controversial [4].
 

Biological context of kuz

  • Furthermore we discuss a second function of Kuzbanian in heart cell morphogenesis [5].
  • Functional analysis revealed a role for the Notch-activating protease Kuzbanian in border cell migration and identified Tie as a guidance receptor for the border cells [6].
  • Taken together these results show that Notch activation and KUZ expression are restricted to border cells at stage 9 of oogenesis and are required for migration, but not differentiation, of these cells [7].
 

Anatomical context of kuz

 

Other interactions of kuz

  • The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs [11].
  • Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE [12].
  • Expression of a dominant negative Kuzbanian protein in the CNS midline cells results in an abnormal midline crossing of axons and prevents the clearance of the Roundabout receptor from commissural axons [8].
  • Our analyses support a model in which Kuzbanian mediates the proteolytic activation of the Slit/Roundabout receptor complex [8].
  • Analysis of the head phenotype suggests that slit may be able to act as an attractive guidance cue while directing the movements of the dorsal ectodermal cell sheath. kuzbanian also regulates midline crossing of CNS axons [8].

References

  1. KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis. Rooke, J., Pan, D., Xu, T., Rubin, G.M. Science (1996) [Pubmed]
  2. kuzbanian-mediated cleavage of Drosophila Notch. Lieber, T., Kidd, S., Young, M.W. Genes Dev. (2002) [Pubmed]
  3. The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors. Yan, Y., Shirakabe, K., Werb, Z. J. Cell Biol. (2002) [Pubmed]
  4. Down-regulation of Delta by proteolytic processing. Mishra-Gorur, K., Rand, M.D., Perez-Villamil, B., Artavanis-Tsakonas, S. J. Cell Biol. (2002) [Pubmed]
  5. The ADAM metalloprotease Kuzbanian is crucial for proper heart formation in Drosophila melanogaster. Albrecht, S., Wang, S., Holz, A., Bergter, A., Paululat, A. Mech. Dev. (2006) [Pubmed]
  6. Analysis of cell migration using whole-genome expression profiling of migratory cells in the Drosophila ovary. Wang, X., Bo, J., Bridges, T., Dugan, K.D., Pan, T.C., Chodosh, L.A., Montell, D.J. Dev. Cell (2006) [Pubmed]
  7. Spatially localized Kuzbanian required for specific activation of Notch during border cell migration. Wang, X., Adam, J.C., Montell, D. Dev. Biol. (2007) [Pubmed]
  8. The function of leak and kuzbanian during growth cone and cell migration. Schimmelpfeng, K., Gögel, S., Klämbt, C. Mech. Dev. (2001) [Pubmed]
  9. Localization of ADAM10 and Notch receptors in bone. Dallas, D.J., Genever, P.G., Patton, A.J., Millichip, M.I., McKie, N., Skerry, T.M. Bone (1999) [Pubmed]
  10. The cell surface metalloprotease/disintegrin Kuzbanian is required for axonal extension in Drosophila. Fambrough, D., Pan, D., Rubin, G.M., Goodman, C.S. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  11. The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs. Sotillos, S., Roch, F., Campuzano, S. Development (1997) [Pubmed]
  12. Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE. Jarriault, S., Greenwald, I. Dev. Biol. (2005) [Pubmed]
 
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