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Gene Review

or  -  orange

Drosophila melanogaster

Synonyms: AP-3sigma, CG3029, Dmel\CG3029, Or, aps3, ...
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High impact information on or

  • Domain swapping and mutagenesis of the Hairy and E(SPL) proteins show that three evolutionarily conserved domains are required for their function: the bHLH, Orange, and WRPW domains [1].
  • The 1064-nm emission from a pulsed Nd:YVO4 laser was used to excite the visible mitochondrial specific dye MitoTracker Orange CM-H2TMRos or a Cy3-labeled antibody by two-photon excitation, and the UV absorbing DNA dyes DAPI and the bisbenzimidazole BBI-342 by three-photon excitation, in a shared aperture SNOM using uncoated fiber tips [2].
  • Hes family of transcriptional repressors with basic Helix-loop-helix (bHLH) and Orange domains are implicated in the cell fate determination of stem cells (or precursor cells) by suppressing the expression of tissue-specific transcriptional activators [3].


  1. Specificity for the hairy/enhancer of split basic helix-loop-helix (bHLH) proteins maps outside the bHLH domain and suggests two separable modes of transcriptional repression. Dawson, S.R., Turner, D.L., Weintraub, H., Parkhurst, S.M. Mol. Cell. Biol. (1995) [Pubmed]
  2. Picosecond multiphoton scanning near-field optical microscopy. Jenei, A., Kirsch, A.K., Subramaniam, V., Arndt-Jovin, D.J., Jovin, T.M. Biophys. J. (1999) [Pubmed]
  3. Identification and characterization of human HES2, HES3, and HES5 genes in silico. Katoh, M., Katoh, M. Int. J. Oncol. (2004) [Pubmed]
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