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Gene Review:

nbs - CG6754 gene product from transcript CG6754-RD

Drosophila melanogaster

Synonyms: 6754, CG6754, Dmel\CG6754, Dnbs1, NBS, ...

Oikemus, S.R. et al., Ciapponi, L. et al.

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High impact information on nbs

Here, we have analyzed the role of the Drosophila nbs gene in telomere protection and the maintenance of chromosome integrity [1].
The telomere fusion phenotype of nbs is consistent with defects in each of these activities [2].

Biological context of nbs

Drosophila nbs is required for both atm- and atr-dependent DNA damage responses and acts in these pathways during DNA repair [2].

References

The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability. Ciapponi, L., Cenci, G., Gatti, M. Genetics (2006) [Pubmed]
Epigenetic telomere protection by Drosophila DNA damage response pathways. Oikemus, S.R., Queiroz-Machado, J., Lai, K., McGinnis, N., Sunkel, C., Brodsky, M.H. PLoS Genet. (2006) [Pubmed]

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