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Gene Review

tefu  -  telomere fusion

Drosophila melanogaster

Synonyms: ATM, Atm, CG6535, Dmel\CG6535, Serine/threonine-protein kinase ATM, ...
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Disease relevance of tefu


High impact information on tefu


Biological context of tefu


Anatomical context of tefu

  • Rescue experiments using a GAL4-driven pUAS transgene demonstrate that tef corresponds to predicted Berkeley Drosophila Genome Project (BDGP) gene CG8961 and that tef expression is required in the male germ line prior to spermatocyte stage S4 [8].

Associations of tefu with chemical compounds

  • Here we report the generation of a null allele of mei-41, Drosophila ATM/ATR homolog, and the use of it to document a semidominant effect on a larval mitotic checkpoint and methyl methanesulfonate (MMS) sensitivity [9].
  • The median effective dose (ED50) for halothane was 0.0096 atm in females and 0.0091 atm in males of the bw;st;svn strain, while in the Eth-29 strain the ED50 was 0.0148 atm in both sexes [10].

Other interactions of tefu


  1. ATM and ATR Pathways Signal Alternative Splicing of Drosophila TAF1 Pre-mRNA in Response to DNA Damage. Katzenberger, R.J., Marengo, M.S., Wassarman, D.A. Mol. Cell. Biol. (2006) [Pubmed]
  2. ATM is required for telomere maintenance and chromosome stability during Drosophila development. Silva, E., Tiong, S., Pedersen, M., Homola, E., Royou, A., Fasulo, B., Siriaco, G., Campbell, S.D. Curr. Biol. (2004) [Pubmed]
  3. Cnd2 has dual roles in mitotic condensation and interphase. Aono, N., Sutani, T., Tomonaga, T., Mochida, S., Yanagida, M. Nature (2002) [Pubmed]
  4. Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect. Oikemus, S.R., McGinnis, N., Queiroz-Machado, J., Tukachinsky, H., Takada, S., Sunkel, C.E., Brodsky, M.H. Genes Dev. (2004) [Pubmed]
  5. Telomere protection without a telomerase; the role of ATM and Mre11 in Drosophila telomere maintenance. Bi, X., Wei, S.C., Rong, Y.S. Curr. Biol. (2004) [Pubmed]
  6. The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability. Ciapponi, L., Cenci, G., Gatti, M. Genetics (2006) [Pubmed]
  7. Epigenetic telomere protection by Drosophila DNA damage response pathways. Oikemus, S.R., Queiroz-Machado, J., Lai, K., McGinnis, N., Sunkel, C., Brodsky, M.H. PLoS Genet. (2006) [Pubmed]
  8. Molecular Characterization of teflon, a Gene Required for Meiotic Autosome Segregation in Male Drosophila melanogaster. Arya, G.H., Lodico, M.J., Ahmad, O.I., Amin, R., Tomkiel, J.E. Genetics (2006) [Pubmed]
  9. Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR. Laurençon, A., Purdy, A., Sekelsky, J., Hawley, R.S., Su, T.T. Genetics (2003) [Pubmed]
  10. Strain differences in minimum anesthetic concentrations in Drosophila melanogaster. Gamo, S., Ogaki, M., Nakashima-Tanaka, E. Anesthesiology (1981) [Pubmed]
  11. The Large Isoform of Drosophila melanogaster Heterochromatin Protein 2 Plays a Critical Role in Gene Silencing and Chromosome Structure. Shaffer, C.D., Cenci, G., Thompson, B., Stephens, G.E., Slawson, E.E., Adu-Wusu, K., Gatti, M., Elgin, S.C. Genetics (2006) [Pubmed]
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