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Gene Review: 

PRY2  -  PTPN13-like, Y-linked 2

Homo sapiens

Synonyms: PTPN13LY2
 
 
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Disease relevance of PRY2

  • PRY1 and PRY2, two gene copies that are located in AZFb, a region often deleted in patients with severe male infertility, were shown to be expressed in the testis [1].
  • Analysis of GenBank-derived clones on the Y chromosome revealed the presence of two full-length copies in azoospermia factor region b (AZFb) (PRY1 and PRY2) and two shorter versions of the PRY gene containing exons 3, 4 and 5 in AZFc (PRY3 and PRY4) [1].
 

High impact information on PRY2

  • Active copies of the PRY gene (PRY1 and PRY2) are located in the AZFb region [2].
 

Other interactions of PRY2

  • Characterization of the genomic organization, localization and expression of four PRY genes (PRY1, PRY2, PRY3 and PRY4) [1].

References

  1. Characterization of the genomic organization, localization and expression of four PRY genes (PRY1, PRY2, PRY3 and PRY4). Stouffs, K., Lissens, W., Van Landuyt, L., Tournaye, H., Van Steirteghem, A., Liebaers, I. Mol. Hum. Reprod. (2001) [Pubmed]
  2. Expression pattern of the Y-linked PRY gene suggests a function in apoptosis but not in spermatogenesis. Stouffs, K., Lissens, W., Verheyen, G., Van Landuyt, L., Goossens, A., Tournaye, H., Van Steirteghem, A., Liebaers, I. Mol. Hum. Reprod. (2004) [Pubmed]
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