Disease relevance of Infertility, Male

• Evidence is presented that the male sterility produced by the mouse t-complex is due to interaction of at least three sterility factors [1].
• CONCLUSIONS: The recognition of adult-onset hypogonadotropic hypogonadism in men as a distinct disorder expands the spectrum of GnRH deficiency and identifies a treatable form of male infertility [2].
• One mus309 allele, which carries a stop codon between two of the helicase motifs, causes partial male sterility and complete female sterility [3].
• Should further elongation of the CAG repeat occur in these future generations, there is an added risk of increased severity of male infertility, and potentially an increased incidence of neurodegenerative disease [4].
• A recent study has shown that the Acinetobacter beta-ketothiolase gene, expressed in the Nicotiana tabacum plastid, conditions maternally inherited male sterility, laying the groundwork for new approaches to control pollen fertility in crop plants [5].

Psychiatry related information on Infertility, Male

• IVF-seeking patients generally desire privacy, even total secrecy, when pursuing these treatments, due to cultural issues of stigmatization, particularly regarding male infertility [6].

High impact information on Infertility, Male

• Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility [7].
• Homozygous methylenetetrahydrofolate reductase C677T mutation and male infertility [8].
• Defects in protamine-2 have been identified in sperm of infertile men, suggesting that our results may have clinical implications for the understanding of human male infertility [9].
• Lack of Ahch causes progressive degeneration of the testicular germinal epithelium independent of abnormalities in gonadotropin and testosterone production and results in male sterility [10].
• Adult-onset idiopathic hypogonadotropic hypogonadism--a treatable form of male infertility [2].

Chemical compound and disease context of Infertility, Male

• Male infertility due to sulphasalazine [11].
• Clomiphene in treatment of male infertility due to isolated follicle-stimulating-hormone deficiency [12].
• Reversal of male infertility on changing treatment from sulphasalazine to 5-aminosalicylic acid [13].
• Treatment of immune male infertility with methylprednisolone [14].
• Levamisole treatment in male infertility due to spermagglutinins [15].

Biological context of Infertility, Male

• We report the phenotype of the first animal mutant in the ubiquitin pathway: inactivation of the hHR6B-homologous gene in mice causes male infertility [16].
• These results demonstrate that in the AE24 mouse line the EGF receptor transgene was integrated into and inactivated an endogenous autosomal gene, causing sperm flagellar axonemal disruption and male sterility [17].
• Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility [18].
• We aimed to find out whether expansion of a trinucleotide repeat in the androgen-receptor gene is associated with male infertility [4].
• Our data suggest that loss of atp6 RNA editing contributes to or causes cytoplasmic male sterility in S. bicolor [19].

Anatomical context of Infertility, Male

• One gene so identified is expressed specifically in testicular germ cells and maps to a subregion of the t-complex also containing loci involved in transmission ratio distortion and male sterility [20].
• The recessive juvenile spermatogonial depletion (jsd) mutation results in a single wave of spermatogenesis, followed by failure of type A spermatogonia to differentiate, resulting in adult male sterility [21].
• Targeted deletion of the SSTK gene in mice resulted in male sterility due to profound impairment in motility and morphology of spermatozoa [22].
• Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis [23].
• It has been suggested that congenital bilateral absence of the vas deferens (CBAVD), an important cause of male infertility, is a variant of cystic fibrosis (CF) [24].

Gene context of Infertility, Male

• Dpl deficiency did not interfere with embryonic and postnatal development, but resulted in male sterility [25].
• Here, we demonstrate that the deletion of Pacrg is the cause of male sterility in the qk(v) mutant [26].
• Loss of Six5 results in male sterility and a progressive decrease in testicular mass with age [27].
• Therefore, the human HOOK1 gene could serve as a candidate gene for male infertility due to teratozoospermia or decapitation defects [28].
• These data raise the possibility that Egr4 may contribute to some forms of human idiopathic male infertility [29].
• This meta-analysis provides support for an association between increased androgen receptor CAG length and idiopathic male infertility, suggesting that even subtle disruptions in the androgen axis may compromise male fertility [30].

Analytical, diagnostic and therapeutic context of Infertility, Male

• In epidemiological studies, male infertility has shown an association with TGCT that is out of proportion with what can be explained by tumor effects [31].
• Use of these partial t haplotypes in genetic crosses has resulted in the general location of the two major t male sterility factors, S1 and S2, within inversions 1 and 4, respectively [32].
• An animal model has been developed which describes ethanol-induced male infertility [33].
• Radiation hybrid mapping places the human tauCstF-64 gene at 10q22-q23, which is the site of a translocation that has been associated with human neurological problems and male infertility [34].
• These data suggest that the decreasing amount of Prm1 and, as a consequence, the aberrant Prm1:Prm2 mRNA ratio plays an important role for male infertility and may serve as a possible predictive factor for the outcome of ICSI [35].

References